42404-23-9

Basic information

• Product Name: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE
• Synonyms: {2-[(4-methylphenyl)thio]ethyl}amine;2-[(4-methylphenyl)thio]ethanamine(SALTDATA: FREE);1-Amino-2-p-tolylthioethane;2-(4-methylphenyl)sulfanylethanamine;2-[(4-Methylphenyl)sulfanyl]ethanamine
• CAS NO: 42404-23-9
• Molecular Formula: C₉H₁₃NS
• Molecular Weight: 167.27
• Mol File: 42404-23-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 267.2°Cat760mmHg
• Flash Point: 115.4°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.00826mmHg at 25°C
• PKA: 8.87±0.10(Predicted)
• CAS DataBase Reference: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE(42404-23-9)
• EPA Substance Registry System: 2-[(4-METHYLPHENYL)THIO]ETHANAMINE(42404-23-9)

Safety Data

• Hazardous Substances Data: 42404-23-9(Hazardous Substances Data)

Usage

Description

2-[(4-METHYLPHENYL)THIO]ETHANAMINE, also known as 4-Methylthioamphetamine (4-MTA), is a synthetic stimulant belonging to the amphetamine class of drugs. It acts as a serotonin-norepinephrine-dopamine releasing agent and a serotonin receptor agonist, producing psychoactive effects such as euphoria, increased energy, and enhanced sensory perception. However, it also carries the risk of serious side effects and toxicity, including overdose, seizures, and cardiovascular complications.

Uses

Used in Research Applications:
4-MTA is used as a research chemical for studying the effects of psychoactive substances on the central nervous system. Its activity as a serotonin-norepinephrine-dopamine releasing agent and a serotonin receptor agonist makes it a valuable tool for understanding the mechanisms of action of amphetamine-based stimulants.
Used in Drug Enforcement and Forensic Analysis:
Due to its classification as a Schedule I controlled substance in the United States, 4-MTA is used in drug enforcement and forensic analysis to identify and track the distribution of illicit substances. Its detection helps law enforcement agencies combat the illegal use and trafficking of this potentially dangerous drug.

InChI:InChI=1/C9H13NS/c1-8-2-4-9(5-3-8)11-7-6-10/h2-5H,6-7,10H2,1H3/p+1

Upstream product

• 10486-08-5 sodium p-thiocresolate 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 106-45-6 para-thiocresol 
• 870-24-6 2-chloroethanamine hydrochloride 
• 497-25-6 dimethylenecyclourethane 
• 82772-76-7 N-<2-<(4-methylphenyl)thio>ethyl>propanamide 
• 87943-20-2 2-phthalimidoethyl p-tolyl sulphide 
• 13989-86-1 2-chloroethylcarbamic acid methyl ester 
• 4528-34-1 2-nitroethanol nitrate 

Downstream Products

• 133760-87-9 1-Phenyl-2-(2-p-tolylsulfanyl-ethylamino)-ethanol 
• 133760-77-7 5-Phenyl-3-(2-p-tolylsulfanyl-ethyl)-oxazolidin-2-one 
• 133760-81-3 4-Phenyl-1-(2-p-tolylsulfanyl-ethyl)-imidazolidin-2-one 
• 1186400-98-5 benzyl (2-(p-tolylthio)ethyl)carbamate 
• 115335-19-8 Benzyl-(2-p-tolylsulfanyl-ethyl)-amine 
• 66860-00-2 2-phenyl-3-(2-p-tolylsulfanyl-ethyl)-thiazolidin-4-one 
• 361145-76-8 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(4-methylphenyl)thio]ethyl}-1-isoindolinone 
• 64276-34-2 2-<<2-<(4-methylphenyl)thio>ethyl>amino>-propanoic acid 
• 53492-62-9 4-methyl-3-[2-(toluene-4-sulfinyl)-ethyl]-sydnone 
• 66859-96-9 benzylidene-(2-p-tolylsulfanyl-ethyl)-amine 

Relevant articles and documents

PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES

The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reac

Base-promoted aminoethylation of thiols with 2-oxazolidinones: A simple synthesis of 2-aminoethyl sulfides

A simple synthesis of 2-aminoethyl sulfides using a base-promoted reaction of 2-oxazolidinones with thiols is described. An application of this method to the synthesis of chiral 2-aminoethyl sulfides and sulfur-containing heterocyclic compounds is also presented.

Elimination-Addition Reactions of 3-sydnones. Displacement of the Sulfide by an Ether Group

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