42509-80-8

Basic information

• Product Name: ISAZOPHOS
• Synonyms: miral10g;o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl)o,o-diethylphosphorothi;o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl)o,o-phosphorothioicaci;o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl)o,o-diethylphosphorothioate;o-5-chloro-1-isopropyl-1h-1,2,4-triazol-3-ylo,o-diethylphosphorothioate;O,O-DIETHYL-O-[1-ISOPROPYL-5-CHLORO-1,2,4-TRIAZOLYL-[3]]-PHOSPHOROTHIOATE;O-DIETHYL-PHOSPHORTHIOATE;O-5-CHLORO-1-ISOPROPYL-1H-1,2,4-TRIAZOLYL-O
• CAS NO: 42509-80-8
• Molecular Formula: C₉H₁₇ClN₃O₃PS
• Molecular Weight: 313.74
• EINECS: 255-863-8
• Product Categories: H-MAnalytical Standards;IPesticides&Metabolites;Alpha sort;Alphabetic;Nematicides;Pesticides;Pesticides&Metabolites;Analytical Standards
• Mol File: 42509-80-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: <25℃
• Boiling Point: bp0.001 100°; bp760 170°
• Flash Point: 188.1°C
• Appearance: /liquid
• Density: 1.22 g/cm3 (20℃)
• Vapor Pressure: 3.3E-06mmHg at 25°C
• Refractive Index: nD20 1.4867
• Storage Temp.: 0-6°C
• PKA: -1.47±0.10(Predicted)
• Water Solubility: 168 mg l-1 (20 °C)
• BRN: 8145294
• CAS DataBase Reference: ISAZOPHOS(CAS DataBase Reference)
• NIST Chemistry Reference: ISAZOPHOS(42509-80-8)
• EPA Substance Registry System: ISAZOPHOS(42509-80-8)

Safety Data

• Hazard Codes: T+,N
• Statements: 24/25-26-43-48/20-50/53
• Safety Statements: 28-36/37-38-45-59-61
• RIDADR: 3018
• WGK Germany: 3
• RTECS: TE7760000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 42509-80-8(Hazardous Substances Data)

Usage

Description

Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is miscible with common organic solvents. Log Kow = 2.99. It is hydrolyzed in aqueous media: DT50 values (20 ?C) at pH 5, 7, and 9 are 85, 48, and 19 d, respectively.

Uses

Different sources of media describe the Uses of 42509-80-8 differently. You can refer to the following data:
1. Isazophos is an organophosphate pesticide.
2. Nematocide; turf insecticide.
3. Isazofos is used as a nematicide and soil insecticide in bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.

Metabolic pathway

Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.

Metabolism

In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.

Toxicity evaluation

Acute oral LD50 for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).

Degradation

Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT50 values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).

InChI:InChI=1/C9H17ClN3O3PS/c1-5-14-17(18,15-6-2)16-9-11-8(10)13(12-9)7(3)4/h7H,5-6H2,1-4H3

Relevant articles and documents

Pesticide compositions and method

Toxicant, especially pesticide compositions, having lowered dermal toxicity are provided. The compositions include a lipophilic-pesticide, a nonionic surfactant and a dry inert diluent carrier. Methods for reducing the dermal toxicity of lipophilic toxicants, especially pesticides are provided, as well as methods for controlling insect pests using the disclosed compositions.