4253-10-5

Basic information

• Product Name: METHYL 3,5-DIIODO-4-METHOXYBENZOATE
• Synonyms: METHYL 3,5-DIIODO-4-METHOXYBENZOATE;3,5-DIIODO-4-METHOXYBENZOIC ACID METHYL ESTER
• CAS NO: 4253-10-5
• Molecular Formula: C₉H₈I₂O₃
• Molecular Weight: 417.97
• Product Categories: Aromatic Esters
• Mol File: 4253-10-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 412.4±45.0 °C(Predicted)
• Appearance: /
• Density: 2.138±0.06 g/cm3(Predicted)
• CAS DataBase Reference: METHYL 3,5-DIIODO-4-METHOXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3,5-DIIODO-4-METHOXYBENZOATE(4253-10-5)
• EPA Substance Registry System: METHYL 3,5-DIIODO-4-METHOXYBENZOATE(4253-10-5)

Safety Data

• Hazardous Substances Data: 4253-10-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 4253-11-6 3,5-Diiodo-4-methoxybenzoic acid 
• 100-09-4 4-methoxybenzoic acid 
• 618-76-8 3,5-diiodo-4-hydroxybenzoic acid 
• 74-88-4 methyl iodide 
• 3337-66-4 methyl 4-hydroxy-3,5-diiodobenzoate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 23964-37-6 3,5-diiodo-4-methoxybenzohydrazide 
• 1422570-70-4 3-(5-(3,5-diiodo-4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride 
• 1422570-03-3 3-(5-(4-hydroxy-3,5-diiodophenyl)-1,3,4-oxadiazol-2-yl)benzene-1-sulfonyl fluoride 
• 35387-93-0 3-iodo-4-methoxy-benzoic acid methyl ester 
• 15126-06-4 methyl 3-iodo-4-hydroxybenzoate 
• 207115-38-6 ethyl 3-iodo-4-methoxybenzoate 
• 121-98-2 methyl 4-methoxybenzoate 
• 94-30-4 ethyl 4-methoxybenzoate 

Relevant articles and documents

Accurate tuning of rare earth metal-organic frameworks with unprecedented topology for white-light emission

A series of isostructural rare-earth metal-organic frameworks (RE-MOFs), namely {[RE(L-X)(H2O)]·2DMF}n (UPC-38, RE = Eu, Tb, X = H, F, Cl, NH2, CH3, OCH3; L = [1,1′:3′,1′′-terphenyl]-4,4′′,5′-tricarbo

Topology Exploration in Highly Connected Rare-Earth Metal-Organic Frameworks via Continuous Hindrance Control

The structural diversity of highly connected metal-organic frameworks (MOFs) has long been limited due to the scarcity of highly connected metal clusters and the corresponding available topology. Herein, we deliberately chose a series of tritopic linkers

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate

Molecules that bind selectively to a given protein and then undergo a rapid chemoselective reaction to form a covalent conjugate have utility in drug development. Herein a library of 1,3,4-oxadiazoles substituted at the 2 position with an aryl sulfonyl fluoride and at the 5 position with a substituted aryl known to have high affinity for the inner thyroxine binding subsite of transthyretin (TTR) was conceived of by structure-based design principles and was chemically synthesized. When bound in the thyroxine binding site, most of the aryl sulfonyl fluorides react rapidly and chemoselectively with the pK a-perturbed K15 residue, kinetically stabilizing TTR and thus preventing amyloid fibril formation, known to cause polyneuropathy. Conjugation t50s range from 1 to 4 min, ～1400 times faster than the hydrolysis reaction outside the thyroxine binding site. X-ray crystallography confirms the anticipated binding orientation and sheds light on the sulfonyl fluoride activation leading to the sulfonamide linkage to TTR. A few of the aryl sulfonyl fluorides efficiently form conjugates with TTR in plasma. Eleven of the TTR covalent kinetic stabilizers synthesized exhibit fluorescence upon conjugation and therefore could have imaging applications as a consequence of the environment sensitive fluorescence of the chromophore.