425379-12-0 Usage
Classification
Organic compound
Belongs to the class of carbon-containing compounds.
Subclass
Imidazopyrimidines
A group of organic compounds characterized by a fused ring structure derived from imidazole and pyrimidine.
Antiviral activity
Inhibitory against human cytomegalovirus (HCMV) and herpes simplex virus (HSV)
Exhibits antiviral properties by interfering with the replication and functioning of the mentioned viruses.
Potential use
Treatment of viral infections
Has been studied for its possible application in treating viral infections, particularly in immunocompromised patients.
Chemical structure
Bromoimidazo triazine ring and a propan-2-ol group
The presence of these functional groups in the compound's structure contributes to its antiviral properties.
Therapeutic potential
Promising as a therapeutic agent against certain viral diseases
Due to its antiviral activity, 2-(3-Bromoimidazo[1,2-b][1,2,4]triazin-7-yl)propan-2-ol shows potential for treating specific viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 425379-12-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,5,3,7 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 425379-12:
(8*4)+(7*2)+(6*5)+(5*3)+(4*7)+(3*9)+(2*1)+(1*2)=150
150 % 10 = 0
So 425379-12-0 is a valid CAS Registry Number.
425379-12-0Relevant articles and documents
Discovery of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxiety
Russell, Michael G. N.,Carling, Robert W.,Street, Leslie J.,Hallett, David J.,Goodacre, Simon,Mezzogori, Elena,Reader, Michael,Cook, Susan M.,Bromidge, Frances A.,Newman, Robert,Smith, Alison J.,Wafford, Keith A.,Marshall, George R.,Reynolds, David S.,Dias, Rebecca,Ferris, Pushpindar,Stanley, Jo,Lincoln, Rachael,Tye, Spencer J.,Sheppard, Wayne F. A.,Sohal, Bindi,Pike, Andrew,Dominguez, Maria,Atack, John R.,Castro, José L.
, p. 1235 - 1238 (2007/10/03)
The identification of a series of imidazo[1,2-b][1,2,4]triazines with high affinity and functional selectivity for the GABAA α3-containing receptor subtype is described, leading to the identification of a clinical candidate, 11. Compound 11 shows good bioavailability and half-life in preclinical species, and it is a nonsedating anxiolytic in both rat and squirrel monkey behavioral models.
IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
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Page/Page column 38, (2010/02/07)
A class of imidazo[1,2b][1,2,4]triazine derivatives, substituted at the 7-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having good affinity for the α2 a
