42574-70-9

Basic information

• Product Name: CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID
• Synonyms: CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID;cis-4-(4-Methyl-piperazin-1-yl)-4-oxo-but-2-enoic
• CAS NO: 42574-70-9
• Molecular Formula: C₉H₁₄N₂O₃
• Molecular Weight: 198.22
• Mol File: 42574-70-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 195.5-196 °C(Solv: acetonitrile (75-05-8))
• Boiling Point: 402.6°C at 760 mmHg
• Flash Point: 197.3°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 1.31E-07mmHg at 25°C
• Refractive Index: 1.537
• PKA: 3.19±0.25(Predicted)
• CAS DataBase Reference: CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID(42574-70-9)
• EPA Substance Registry System: CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID(42574-70-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42574-70-9(Hazardous Substances Data)

Usage

General Description

CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID is a chemical compound with the molecular formula C11H18N2O3. It is a derivative of piperazine and is commonly used in the pharmaceutical industry for the synthesis of various drugs. CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID has been found to exhibit potential therapeutic effects, particularly in the treatment of neurological disorders and as an antipsychotic agent. Its chemical structure includes a piperazine ring and a butenolide moiety, both of which contribute to its biological activity and pharmacological properties. Further research and studies are ongoing to explore the full potential and applications of CIS-4-(4-METHYL-PIPERAZIN-1-YL)-4-OXO-BUT-2-ENOIC ACID in the field of medicine and drug development.

InChI:InChI=1/C9H14N2O3/c1-10-4-6-11(7-5-10)8(12)2-3-9(13)14/h2-3H,4-7H2,1H3,(H,13,14)/b3-2-

Upstream product

• 109-01-3 1-methyl-piperazine 
• 108-31-6 maleic anhydride 

Downstream Products

• 1313395-65-1 (Z)-4-(4-methylpiperazin-1-yl)-4-oxo-N-(m-tolyl)but-2-enamide 
• 1313395-76-4 (E)-4-(4-methylpiperazin-1-yl)-4-oxo-N-(m-tolyl)but-2-enamide 

Relevant articles and documents

Experimental and theoretical investigation of the reaction of secondary amines with maleic anhydride

The reaction of secondary amines, namely 1-methylpiperazine, pyrrolidine, morpholine, 2-methylpiperidine, and diethylamine, with maleic anhydride has been investigated experimentally and theoretically at the DFT level. Under kinetic control, i.e. at -78°C

A facile precursor route to transition metal molybdates using a polyzwitterionic matrix bearing simultaneously charged moieties and complexing groups

An unconventional but easily accessible precursor route involving the thermal treatment of hybrid precursors containing an ampholytic polymer matrix is developed to prepare multimetallic oxides of catalytic interest such as transition metal molybdates. A copolymer of diallyldimethylammonium chloride and a functionalized maleamic acid bearing an amine group suited for cation complexation was designed, synthesized and used as a matrix to stabilize inorganic species generated in solution from Ni(NO3) 2·6H2O, Co(NC3)2· 6H2O and/or Mn(NO3)2·4H2O together with (NH4)6Mo7O24· 4H2O. UV-vis-NIR as well as 13C-NMR studies suggest that the interactions between the cations and the polymer in solution are mainly electrostatic. Only minor complexation interactions take place under certain conditions. Homogeneous hybrid blends were prepared from these solutions. The presence of a complexing amine group in addition to the charged betaine moieties in the polymer permits stabilization of more than stoichiometric amounts of the metal species in the blends. XRD measurements suggest that the homogeneity in the solid state can be kept up to about 1.5 mol of each metal that is incorporated (anionic as well as cationic) per mol of repeat units of the copolymer. The blends were calcined under air at 600°C to produce the simple as well as mixed nickel, cobalt and manganese molybdates. Characterization of the final phases by XRD and Raman spectroscopy indicates that the α- as well as the β-molybdate phases can be prepared, and that the mixed structures are solid solutions of the simple NiMoO4, MnMoO 4 and CoMoO4 If the precursors engaged are homogeneous, the pH of the precursor solution, the amount of metal that is incorporated in the matrix, and the nature of the polymer matrix seem to exert only a minor influence on the nature of the final phase, which demonstrates the versatility and facile applicability of the method. The Royal Society of Chemistry 2005.