426463-05-0 Usage
Description
2-Chloro-5-iodo-3-nitropyridine is an organic compound characterized by its unique molecular structure, featuring a pyridine ring with a chlorine atom at the 2nd position, an iodine atom at the 5th position, and a nitro group at the 3rd position. 2-Chloro-5-iodo-3-nitropyridine is known for its potential applications in the synthesis of various nitrogen heterocycles, particularly those with biological and pharmaceutical relevance.
Uses
Used in Pharmaceutical Industry:
2-Chloro-5-iodo-3-nitropyridine is used as a key intermediate in the synthesis of nitrogen heterocycles, which are essential for the development of novel drugs targeting the colony stimulating factor-1 receptor (CSF-1R). These CSF-1R inhibitors play a crucial role in regulating the immune system and have potential applications in the treatment of various diseases, including cancer and autoimmune disorders.
In the preparation of nitrogen heterocycles, 2-Chloro-5-iodo-3-nitropyridine serves as a valuable building block due to its reactive functional groups, which can be further modified to create a diverse range of biologically active molecules. 2-Chloro-5-iodo-3-nitropyridine's unique structure allows for the design of targeted therapies with improved specificity and reduced side effects, making it a promising candidate for drug development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 426463-05-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,6,4,6 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 426463-05:
(8*4)+(7*2)+(6*6)+(5*4)+(4*6)+(3*3)+(2*0)+(1*5)=140
140 % 10 = 0
So 426463-05-0 is a valid CAS Registry Number.
426463-05-0Relevant articles and documents
PROTEIN KINASE INHIBITORS
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, (2015/02/18)
A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.
ANTI-FIBROTIC PYRIDINONES
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, (2014/04/17)
Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin- 7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain
Giblin, Gerard M. P.,Billinton, Andrew,Briggs, Michael,Brown, Andrew J.,Chessell, Iain P.,Clayton, Nick M.,Eatherton, Andrew J.,Goldsmith, Paul,Haslam, Carl,Johnson, Matthew R.,Mitchell, William L.,Naylor, Alan,Perboni, Alcide,Slingsby, Brian P.,Wilson, Alex W.
supporting information; experimental part, p. 5785 - 5788 (2010/02/28)
We report the synthesis and SAR of a series of novel azaindole CB 2 agonists. 6-Azaindole 18 showed activity in an acute pain model but was inactive in a chronic model. 18 is a Pgp substrate with low brain penetration. The template was redesign
