42749-28-0

Basic information

• Product Name: PEG7-Tos
• Synonyms: PEG7-Tos;Tos-PEG6-OH
• CAS NO: 42749-28-0
• Molecular Formula: C₁₉H₃₂O₉S
• Molecular Weight: 436.51698
• Mol File: 42749-28-0.mol
• Article Data: 65

Chemical Properties

• Boiling Point: 555.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: PEG7-Tos(CAS DataBase Reference)
• NIST Chemistry Reference: PEG7-Tos(42749-28-0)
• EPA Substance Registry System: PEG7-Tos(42749-28-0)

Safety Data

• Hazardous Substances Data: 42749-28-0(Hazardous Substances Data)

Usage

Description

PEG7-Tos is a PEG linker containing a hydroxyl group with a tosyl group, which is known for its excellent leaving group properties in nucleophilic substitution reactions. The hydrophilic PEG spacer significantly enhances solubility in aqueous media, while the hydroxyl group allows for further derivatization or replacement with other reactive functional groups, making PEG7-Tos a versatile molecule for various applications.

Uses

Used in Pharmaceutical Industry:
PEG7-Tos is used as a solubility enhancer for improving the aqueous solubility of hydrophobic drugs, facilitating their absorption and bioavailability. The hydroxyl group in PEG7-Tos can be derivatized or replaced with drug molecules or other functional groups, enabling the development of novel drug conjugates and prodrugs with enhanced properties.
Used in Chemical Synthesis:
PEG7-Tos is used as a versatile building block in the synthesis of various bioactive molecules and polymers. The hydroxyl group allows for further functionalization, while the tosyl group serves as a good leaving group in nucleophilic substitution reactions, making PEG7-Tos a valuable intermediate in the preparation of complex molecules.
Used in Drug Delivery Systems:
PEG7-Tos is used as a component in the design of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The hydrophilic PEG spacer improves the stability and solubility of these systems in aqueous environments, while the hydroxyl group can be used to attach drug molecules or targeting ligands, enhancing the specificity and efficacy of the delivery system.
Used in Bioconjugation:
PEG7-Tos is used as a bioconjugation agent to attach biologically active molecules, such as proteins, peptides, or nucleic acids, to other molecules or surfaces. The hydroxyl group can be reacted with functional groups on the biomolecule, while the tosyl group ensures efficient coupling, resulting in stable and well-defined bioconjugates for various applications, including diagnostics, therapeutics, and biosensing.

Upstream product

• 2615-15-8 pentaethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1821464-56-5 35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl 4-methylbenzenesulfonate 
• 1123221-87-3 C₁₉H₃₂O₈ 
• 155990-31-1 NH(CH₂CH₂NHCH₂CH₂NCHC₆H₃(OH)OCH₂(CH₂OCH₂)5CH₂OH)2 
• 393517-91-4 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 
• 669556-59-6 1-{2-[2-(2-{2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-4-methoxy-benzene 
• 669556-53-0 2-{2-[2-(2-{2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-tetrahydro-pyran 

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