42754-96-1

Basic information

• Product Name: 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
• Synonyms: 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro-;4,6-dichloropyrrolo[2,3-d]pyrimidine;4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine;4,6-Dichloropyrazolo[3,4-d]pyriMidine;6-Dichloro-1H-pyrazolo[3;4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine;4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(RS20012005)
• CAS NO: 42754-96-1
• Molecular Formula: C₅H₂Cl₂N₄
• Molecular Weight: 189
• EINECS: 948-193-9
• Product Categories: CHIRAL CHEMICALS;Building Blocks;Pyrazolo[x,x-y]pyridine;Aromatics;Heterocycles;Heterocycle-Pyrimidine series
• Mol File: 42754-96-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 145 °C (decomp)
• Boiling Point: 251.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.792 g/cm³
• Refractive Index: 1.742
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.90±0.20(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(42754-96-1)
• EPA Substance Registry System: 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(42754-96-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45-24/25
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 42754-96-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C5H2Cl2N4/c6-3-2-1-8-11-4(2)10-5(7)9-3/h1H,(H,8,9,10,11)

Upstream product

• 184764-63-4 4,6-dihydroxypyrazolo[3,4-d]pyrimidine 
• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 302-01-2 hydrazine 
• 2465-59-0 oxypurinol 

Downstream Products

• 1017246-05-7 6-chloro-4-(cyclohexylmethoxy)-1H-pyrazolo[3,4-d]pyrimidine 
• 1017246-06-8 4-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-benzenesulfonamide 
• 1017246-07-9 C₁₁H₈ClN₅ 
• 1037479-62-1 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1Hpyrazolo [3 ,4-d]pyrimidine 
• 1037479-82-5 4,6-dichloro-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[3,4-d]pyrimidine 
• 1144080-48-7 6-chloro-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1594133-98-8 6-chloro-4-(3-nitrophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1594133-99-9 N-(3-(6-((3-morpholinophenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide 
• 1594133-89-7 N-(3-(6-((3-morpholinophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide 
• 1594134-00-5 N-(3-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide 
• 1594133-91-1 N-(3-(3-chloro-6-((3-morpholinophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide 
• 7251-92-5 6-chloro-N-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 

Relevant articles and documents

SHP2 INHIBITORS AND USES THEREOF

Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

COMPOUNDS

Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).

LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME

Compounds having the formula (I), (II), (III) are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.