42823-46-1

Basic information

• Product Name: 4-Guanidinobenzoic acid hydrochloride
• Synonyms: 4-GUANIDOBENZOIC ACID HYDROCHLORIDE;4-GUANIDINOBENZOIC ACID HCL;4-GUANIDINOBENZOIC ACID HYDROCHLORIDE;TIMTEC-BB SBB003396;N-(4-CARBOXYPHENYL)GUANIDINE HYDROCHLORIDE;4-GUANIDINOBENZOIC ACID HCL CRYST;4-GUANIDINOBENZOIC ACID HYDROCHLORIDE, 9 9%;4-GUANIDINOBENZOIC ACID HYDROCHLORIDE 95+%
• CAS NO: 42823-46-1
• Molecular Formula: C₈H₉N₃O₂*ClH
• Molecular Weight: 215.64
• EINECS: 255-956-3
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Miscellaneous Reagents;Building Blocks;Chemical Synthesis;Guanidines;Nitrogen Compounds;Organic Building Blocks;nucleoside
• Mol File: 42823-46-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 285 °C (dec.)(lit.)
• Boiling Point: 438.4 °C at 760 mmHg
• Flash Point: 218.9 °C
• Appearance: Off-white solid
• Storage Temp.: 0-6°C
• Solubility: DMSO,(Slightly) Methanol (Slightly), Water (Slightly)
• Water Solubility: soluble
• BRN: 3718032
• CAS DataBase Reference: 4-Guanidinobenzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Guanidinobenzoic acid hydrochloride(42823-46-1)
• EPA Substance Registry System: 4-Guanidinobenzoic acid hydrochloride(42823-46-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 42823-46-1(Hazardous Substances Data)

Usage

Description

4-Guanidinobenzoic acid hydrochloride is a guanidine derivative characterized by its off-white solid appearance. It has been investigated for its quality standard and is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
4-Guanidinobenzoic acid hydrochloride is used as an active pharmaceutical ingredient for the treatment of chronic inflammatory diseases. Its guanidine structure allows it to potentially modulate inflammatory pathways and provide therapeutic benefits to patients suffering from such conditions.
Used in Research and Development:
In the field of research, 4-Guanidinobenzoic acid hydrochloride is utilized in the ELISA inhibition assay of mouse antiserum. This application aids in the study of immune responses and the development of diagnostic tools.
Used in Synthesis of Biochemical Compounds:
4-Guanidinobenzoic acid hydrochloride is also employed in the synthesis of human acrosin inhibitor 4′-acetaminophenyl 4-guanidinobenzoate hydrochloride. 4-Guanidinobenzoic acid hydrochloride has potential applications in the field of reproductive health and fertility, as acrosin is an enzyme involved in the fertilization process.

InChI:InChI=1S/C8H9N3O2.ClH/c9-8(10)11-6-3-1-5(2-4-6)7(12)13;/h1-4H,(H,12,13)(H4,9,10,11);1H

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 1627898-15-0 2-[(4-cyanophenyl)amino]-4,6-dimethoxypyrimidine 
• 156-62-7 calcium cyanamide 
• 420-04-2 CYANAMID 

Downstream Products

• 89022-08-2 4'-Carboethoxyphenyl 4-guanidinobenzoate hydrochloride 
• 79126-26-4 4-Guanidino-benzoic acid 3-methoxy-phenyl ester 
• 100019-78-1 4-Guanidino-benzoic acid 3-cyano-phenyl ester; hydrochloride 
• 80532-07-6 4-(β-amidinoethenyl)phenyl 4-guanidinobenzoate 
• 80532-08-7 4-amidino-2-benzoylphenyl 4-guanidinobenzoate 
• 99966-61-7 4-Guanidino-benzoic acid 4-cyano-phenyl ester; compound with toluene-4-sulfonic acid 
• 99966-59-3 4-Guanidino-benzoic acid 4-butoxy-phenyl ester 
• 99966-57-1 4-Guanidino-benzoic acid 4-chloro-phenyl ester; compound with toluene-4-sulfonic acid 
• 99966-58-2 4-Guanidino-benzoic acid 4-methoxy-phenyl ester 
• 26173-48-8 4'-Carbomethoxyphenyl 4-guanidinobenzoate hydrochloride 
• 89022-09-3 4-((Aminoiminomethyl)amino)benzoic acid 2-(aminocarbonyl)phenyl ester hydrochloride 
• 16060-65-4 4-guanidinobenzoic acid 
• 869363-13-3 4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid 
• 775263-30-4 ethyl 7-[(4-guanidinobenzoyl)amino]-1,2,3,4-tetrahydronaphthalene-2-acetate 

Relevant articles and documents

Preparation method and application of Nafamostat mesylate intermediate

The invention belongs to the field of intermediate preparation and particularly relates to a preparation method and the application of a Nafamostat mesylate intermediate. The preparation method of theNafamostat mesylate intermediate comprises the step of enabling o/p-aminobenzoic acids to react with cyanamide under the action of a catalyst in a solvent, wherein the catalyst is hydrochloric acid ethanol or hydrochloric acid methanol and preferably selects the hydrochloric acid ethanol. The invention further provides a method for further preparing a Nafamostat mesylate impurity standard productby utilizing the method. With the adoption of the preparation method of the Nafamostat mesylate intermediate, the reaction time is shortened, the reaction yield is improved, and the production cost and the storage pressure are reduced. Therefore, implementation values and social economic benefits are greater. Moreover, impurities in the Nafamostat mesylate production are qualitatively and quantitatively analyzed by the impurity standard product, so that the quality standard of the product can be improved, and an important guiding significance is provided for safe medication.

Cleavage of 2-(Arylamino)-4,6-dimethoxypyrimidines to yield arylguanidines

A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4,6-dimethoxypyrimidines, which were prepared by coupling aryl bromides with 2-amino-4,6-dimethoxypyrimidine. This methodology introduces a new means of protection for the guanidine functionality. Copyright

Methods and compositions for treating or preventing bacterial infection

The invention relates to compositions and methods for treating or preventing disease or disorders caused by or associated with certain bacterial infection, especially Escherichia coli (E. coli) or Helicobacter pylori (H. pylori) infection.