4284-47-3

Basic information

• Product Name: N-(4-methylphenyl)methanesulfonamide
• Synonyms: N-(4-methylphenyl)methanesulfonamide
• CAS NO: 4284-47-3
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24344
• Mol File: 4284-47-3.mol
• Article Data: 35

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methylphenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)methanesulfonamide(4284-47-3)
• EPA Substance Registry System: N-(4-methylphenyl)methanesulfonamide(4284-47-3)

Safety Data

• Hazardous Substances Data: 4284-47-3(Hazardous Substances Data)

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 20277-69-4 sodium methansulfinate 
• 3144-09-0 methanesulfonamide 
• 624-31-7 4-tolyl iodide 
• 93131-73-8 4-tolyl perfluorobutanesulfonate 
• 106-43-4 para-chlorotoluene 
• 106-44-5 p-cresol 
• 106-38-7 para-bromotoluene 
• 124-63-0 methanesulfonyl chloride 
• 54378-81-3 C₂₇H₂₆NO₄PS₂ 
• 106-49-0 p-toluidine 
• 5720-05-8 4-methylphenylboronic acid 
• 624-90-8 Methanesulfonyl azide 

Downstream Products

• 109495-72-9 N-(2-chloro-4-methylphenyl)methanesulfonamide 
• 114723-63-6 methanesulfonic acid-(2,3,5,6-tetrachloro-4-methyl-anilide) 
• 10355-06-3 methyl 3-methylphenyl sulfone 

Relevant articles and documents

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorinating agent for the in-situ conversion of aldehydes to nitrile oxides in the presence of hydroxylamine hydrochloride, under ultrasound activation. These nitrile oxides could be engaged in 1,3-dipolar cycloaddition reactions with various alkene to afford the targeted sulfonamides-isoxazolines hybrids (3a-r). The latter were assessed for their antineoplastic activity against model leukemia cell lines (Chronic Myeloid Leukemia, K562 and Promyelocytic Leukemia, HL-60).

Copper-catalyzed redox coupling of nitroarenes with sodium sulfinates

A simple copper-catalyzed redox coupling of sodium sulfinates and nitroarenes is described. In this process, abundant and stable nitroarenes serve as both the nitrogen sources and oxidants, and sodium sulfinates act as both reactants and reductants. A variety of aromatic sulfonamides were obtained in moderate to good yields with broad substrate scope. No external additive is employed for this kind of transformation.

Continuous-Flow Electrosynthesis of Benzofused S-Heterocycles by Dehydrogenative C?S Cross-Coupling

Reported herein is the synthesis of benzofused six-membered S-heterocycles by intramolecular dehydrogenative C?S coupling using a modular flow electrolysis cell. The continuous-flow electrosynthesis not only ensures efficient product formation, but also obviates the need for transition-metal catalysts, oxidizing reagents, and supporting electrolytes. Reaction scale-up is conveniently achieved through extended electrolysis without changing the reaction conditions and equipment.