42874-16-8Relevant articles and documents
Synthesis method of 2-chloro-4-trifluoromethylphenyl-4'-nitro-3'-ethyoxyl phenyl ether
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Paragraph 0007; 0028-0030; 0032-0034; 0036-0038; 0040-0042, (2021/11/26)
The invention discloses a synthesis method of 2-chloro-4-trifluoromethylphenyl-4'-nitro-3'-ethyoxyl phenyl ether. The technical scheme is as follows: 3-chloro-4-nitrophenol and 3, 4-dichlorobenzotrifluoride are used as starting raw materials, under the action of a catalyst and alkali, a reaction liquid is fully mixed by acoustic resonance, heating is performed for reacting for a certain time to obtain an intermediate 2-chloro-4-trifluoromethylphenyl-4'-nitro-3'-chlorobenzene; and the intermediate 2-chloro-4-trifluoromethylphenyl-4'-nitro-3'-chlorobenzene reacts with ethanol salt to obtain the target product 2-chloro-4-trifluoromethylphenyl-4'-nitro-3'-ethyoxyl phenyl ether. The synthesis method adopted by the invention has the advantages of few reaction steps, simplicity in operation, high mixing efficiency, mild conditions, few three wastes and high yield, and is a synthesis method capable of industrializing 2-chloro-4-trifluoromethylphenyl-4'-nitro-3'-ethoxyphenyl ether; and the invention belongs to the field of pesticide synthesis.