428871-64-1

Basic information

• Product Name: 2-Amino-5-chloro-4-fluoronitrobenzene
• Synonyms: 2-Amino-5-chloro-4-fluoronitrobenzene;4-Chloro-5-fluoro-2-nitroaniline;(4-Chloro-5-fluoro-2-nitrophenyl)amine
• CAS NO: 428871-64-1
• Molecular Formula: C₆H₄ClFN₂O₂
• Molecular Weight: 190.5595632
• Mol File: 428871-64-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 321.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.591±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -2.14±0.25(Predicted)
• CAS DataBase Reference: 2-Amino-5-chloro-4-fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-chloro-4-fluoronitrobenzene(428871-64-1)
• EPA Substance Registry System: 2-Amino-5-chloro-4-fluoronitrobenzene(428871-64-1)

Safety Data

• Hazardous Substances Data: 428871-64-1(Hazardous Substances Data)

Usage

General Description

2-Amino-5-chloro-4-fluoronitrobenzene is a chemical compound with the formula C6H4ClFNO2. It is a derivative of nitrobenzene, which is commonly used in the synthesis of various pharmaceuticals and other organic compounds. 2-Amino-5-chloro-4-fluoronitrobenzene contains an amino group, a chlorine atom, and a fluorine atom attached to a nitrobenzene ring, making it a versatile building block in organic chemistry. It has the potential for use in the pharmaceutical industry as a precursor for the synthesis of various active pharmaceutical ingredients, as well as in the synthesis of agrochemicals and dyes. However, as a nitro compound, it should be handled with caution due to its potential toxicity and environmental impact.

Upstream product

• 351-31-5 N-(4-chloro-3-fluorophenyl)acetamide 
• 367-22-6 4-chloro-3-fluoroaniline 
• 1026523-37-4 N-(4-Chloro-5-fluoro-2-nitro-phenyl)-acetamide 

Downstream Products

• 626237-61-4 4-chloro-5-(4-ethyl-2-methylpiperazin-1-yl)-2-nitroaniline 
• 579474-20-7 (4-chloro-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester 
• 428870-62-6 tert-butyl 4-(5-amino-2-chloro-4-nitrophenyl)piperazine-1-carboxylate 
• 139512-70-2 4-chloro-5-fluorobenzene-1,2-diamine 
• 413597-37-2 1,2-diamino-4-fluoro-5-(4-phenyl-1-piperazinyl)benzene 

Relevant articles and documents

ANDROGEN RECEPTOR ANTAGONISTS

Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.

Benzimidazole derivatives

This invention provides compounds which are represented by a general formula [I] [in which X stands for hydrogen or halogen; B stands for halogen, cyano or optionally fluorine-substituted lower alkyl; D stands for a 3-10 membered aliphatic nitrogen-containing heterocyclic group; R3, R4 and R5 may be same or different, and each stands for hydrogen, lower alkyl optionally having substituent group(s) and the like; and a is 0 or 1]. These compounds exhibit high affinity to nociceptin receptors and whereby inhibit actions of nociceptin, and are useful as an analgesic, antiobestic, agent for ameliorating brain function, treating agents for Alzheimer's disease and dementia, and therapeutic agents for schizophrenia, neurodegenerative diseases, depression, diabetes insipidus, polyuria, hypotension and the like.