42897-50-7

Basic information

• Product Name: S-benzyl-N-chloromethylsulfonylisothiourea
• CAS NO: 42897-50-7
• Molecular Weight: 278.784
• Mol File: 42897-50-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: S-benzyl-N-chloromethylsulfonylisothiourea(CAS DataBase Reference)
• NIST Chemistry Reference: S-benzyl-N-chloromethylsulfonylisothiourea(42897-50-7)
• EPA Substance Registry System: S-benzyl-N-chloromethylsulfonylisothiourea(42897-50-7)

Safety Data

• Hazardous Substances Data: 42897-50-7(Hazardous Substances Data)

Upstream product

• 3518-65-8 monochloromethanesulfonyl chloride 
• 538-28-3 S-benzylisothiourea hydrochloride 
• 621-85-2 S-benzyl isothiocarbamide 

Downstream Products

• 201363-00-0 3-Benzylsulfanyl-1,1-dioxo-1,5-dihydro-1λ⁶-[1,2,4]thiadiazole-4-carboxylic acid tert-butyl ester 
• 53826-44-1 3-benzylsulfanyl-1,1-dioxo-1,5-dihydro-1λ⁶-[1,2,4]thiadiazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Sulfonamide analogues of creatinine. The synthesis of 3-amino-4,5-dihydro-l,2,4-thiadiazole 1,1-dioxides from base-induced cyclization reactions

We report the preparation of 3-amino-4,5-dihydro-l,2,4-thiadiazole 1,1-dioxide and of its 4-methyl derivative which are of interest as potential analogues of creatinine. The thiadiazoles are obtained from chloromethylsulfonylation of S-benzylisothiourea, followed by cyclization of the chloromethanesulfonamide under basic conditions in the presence of 2-(t-butoxycarbonyloxyimino)-2-phenylacetonitrile or of methyl iodide.