429621-61-4

Basic information

• Product Name: 2-(N-(p-nitro)phenylamino)-4-phenylthiazole
• Synonyms: 2-(N-(p-nitro)phenylamino)-4-phenylthiazole
• CAS NO: 429621-61-4
• Molecular Weight: 297.337
• Mol File: 429621-61-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(N-(p-nitro)phenylamino)-4-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-(p-nitro)phenylamino)-4-phenylthiazole(429621-61-4)
• EPA Substance Registry System: 2-(N-(p-nitro)phenylamino)-4-phenylthiazole(429621-61-4)

Safety Data

• Hazardous Substances Data: 429621-61-4(Hazardous Substances Data)

Upstream product

• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 3696-22-8 p-nitrophenylthiourea 
• 4098-17-3 1-(1-azido-2-iodoethyl)benzene 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 1619-40-5 N¹-(4-phenylthiazol-2-yl)benzene-1,4-diamine 

Relevant articles and documents

Aryliodoazide synthons: A different approach for diversified synthesis of 2-aminothiazole, 1,3-thiazole, and 1,3-selenazole scaffolds

Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.

Antibacterial synergist, preparation method and uses thereof

The present invention relates to an antibacterial synergist, a preparation method and uses thereof, and specifically discloses a compound represented by a formula (I) and having antibacterial synergyactivity, or an optical isomer, a cis-trans isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. The present invention further discloses a medical composition containing the compound, and uses thereof. According to the present invention, the compound can effectively enhance the antibacterial activity of polymyxin B against Acinetobacter baumannii and Klebsiella pneumoniae, and can be used for the antibacterial treatment of pathogenic bacteria insensitive to polymyxin or having low bacterial inhibition activity. The formula (I) is defined in the specification.

Effect of substituents on the regioselectivity of the reaction of α-tosyloxyketones with thioureas in acidic medium: Access to 2-aminothiazoles and 2-imino-2,3-dihydrothiazoles

Regioselective condensation of α-tosyloxyacetophenones 1 and N-substituted thioureas 2 in acidic medium to give regioisomers 2-aminothiazoles I and 2-imino-2,3-dihydrothiazoles II is largely influenced by the substituents present on 1 and 2. A mechanism,