429649-34-3 Usage
Main Properties
1. Chemical Name: 2-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-6-methylpyrimidin-4(1H)-one
2. Common Name: EGCG analog
3. Function: Potential antioxidant and anti-inflammatory compound
4. Source: Derivative of epigallocatechin gallate (EGCG), a catechin found in green tea
5. Structural Similarity: Similar to EGCG compound
6. Research Focus: Investigated for cancer therapy, anti-inflammatory effects, neuroprotection, and lipid metabolism modulation
Specific Content
1. Antioxidant Properties: Potential ability to neutralize free radicals and oxidative stress.
2. Anti-inflammatory Effects: Ability to reduce inflammation in various cell and animal models.
3. Cancer Therapy: Promising results in inhibiting the growth of cancer cells.
4. Neuroprotection: Investigated for potential protective effects on the nervous system.
5. Lipid Metabolism Modulation: Studied for its influence on lipid metabolism.
6. Need for Further Research: Further investigation required to fully understand mechanisms of action and therapeutic applications.
Antioxidant
A substance that inhibits oxidation, protecting cells from damage caused by free radicals.
Anti-inflammatory
Capable of reducing inflammation, which is the body's response to injury or infection.
Cancer Therapy
Treatment or prevention strategies targeting cancerous cells to inhibit their growth or induce cell death.
Neuroprotective
Having properties that protect nerve cells from damage or degeneration.
Lipid Metabolism
Processes involved in the synthesis, breakdown, and transport of fats (lipids) in the body.
Mechanisms of Action
Processes by which a compound exerts its effects on biological systems.
Therapeutic Applications
Potential uses of a compound for treating or managing medical conditions.
This compound, while showing promise in various areas, requires more extensive research to determine its effectiveness and safety for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 429649-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,9,6,4 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 429649-34:
(8*4)+(7*2)+(6*9)+(5*6)+(4*4)+(3*9)+(2*3)+(1*4)=183
183 % 10 = 3
So 429649-34-3 is a valid CAS Registry Number.
429649-34-3Relevant articles and documents
Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer
Bantzi, Marina,Augsburger, Fiona,Loup, Jérémie,Berset, Yan,Vasilakaki, Sofia,Myrianthopoulos, Vassilios,Mikros, Emmanuel,Szabo, Csaba,Bochet, Christian G.
, p. 6221 - 6240 (2021)
The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency. Among those, (2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one) or HMPSNE was found to be the most potent and selective. We now took the central core of this compound and modified the pyrimidone and the arylketone sides independently. A 63-compound library was synthesized; compounds were tested for H2S generation from recombinant 3-MST in vitro. Active compounds were subsequently tested to elucidate their potency and selectivity. Computer modeling studies have delineated some of the key structural features necessary for binding to the 3-MST's active site. Six novel 3-MST inhibitors were tested in cell-based assays: they exerted inhibitory effects in murine MC38 and CT26 colon cancer cell proliferation; the antiproliferative effect of the compound with the highest potency and best cell-based activity (1b) was also confirmed on the growth of MC38 tumors in mice.
