429659-01-8Relevant articles and documents
A novel benzimidazole pyridine salt compound and its synthetic method (by machine translation)
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Paragraph 0058, (2019/10/02)
The present invention provides a benzimidazole pyridine salt compound, its pharmaceutically acceptable salts, solvates, isomers, their metabolites form, or their mixtures, and the synthetic method of the compound, the compound has anticoagulant effect, and potentially of officinal property, can be used for the prevention or treatment of thrombin active disease related to use. (by machine translation)
METHOD FOR PREPARING DABIGATRAN ETEXILATE INTERMEDIATE, AND INTERMEDIATE COMPOUND
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Paragraph 0064, (2017/08/01)
Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises; reacting a compound 3 with a C1-C3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X=chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.
A darbey adds the group ester method for the preparation of intermediates
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Paragraph 0032-0033, (2017/03/08)
The invention discloses a preparation method of a dabigatran etexilate intermediate. The preparation method of the dabigatran etexilate intermediate 2 comprises that in an aprotic organic solvent, a compound 1 and a C1-C3 alkyl alcohol solution of methylamine undergo a reaction to produce the dabigatran etexilate intermediate, wherein X represents chlorine, bromine or iodine. The preparation method of the dabigatran etexilate intermediate has simple processes, can be operated easily, has a high reaction rate and a high yield, can be purified easily and can produce the product having high purity.