42990-70-5Relevant articles and documents
Diastereoselective Synthesis of α-Bromo amides leading to Diastereomerically Enriched α-Amino-, α-Hydroxy- and α-Thiocarboxylic Acid Derivatives
Ward, Robert S.,Pelter, Andrew,Goubet, Dominique,Pritchard, Martyn C.
, p. 469 - 498 (1995)
α-Bromo amides derived from Oppolzer's camphorsultam can be prepared diastereoselectively starting from racemic α-bromo acids, and undergo epimerisation under appriopriate conditions leading to an enhanced d.e..By reacting the individual isomers or the mi
Amino acid group S - carboxyl ring internal anhydride and functionalized polythioester and preparation method thereof (by machine translation)
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Paragraph 0108-0111, (2020/09/09)
The invention relates to amino acid group S - carboxyl ring internal anhydride and functionalized polythioester and a preparation method thereof, and belongs to the technical field of polymer preparation. The amino acid group S - carboxyl ring internal an
N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
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, (2008/06/13)
Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-α converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-α from membrane bound TNF-α precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-α converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R2and R3form a heterocyclic ring and A is S, S(O), or S(O)2, and R1and R4are defined herein.