43077-30-1 Usage
Biological Activity
Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
Check Digit Verification of cas no
The CAS Registry Mumber 43077-30-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,7 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 43077-30:
(7*4)+(6*3)+(5*0)+(4*7)+(3*7)+(2*3)+(1*0)=101
101 % 10 = 1
So 43077-30-1 is a valid CAS Registry Number.
InChI:InChI=1/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1
43077-30-1Relevant articles and documents
Stereochemistry of Nucleophilic Substitution of Menthyl Derivatives with Anion of Diphenylphosphine Oxide by an Action of Sodium Dihydridobis(2-methoxyethanolato)aluminate
Yamashita, Mitsuji,Soeda, Yukio,Suzuki, Nobuyoshi,Yamada, Manabu,Tsunekawa, Kenji,et al.
, p. 1871 - 1872 (1983)
The reaction of an anion of diphenylphosphine oxide prepared by the action of sodium dihydridobis(2-methoxyethanolato)aluminate on the oxide with various menthyl or neomenthyl halides and sulfonates were studied to clarify the sterochemistry of the substi
Synthesis of novel chiral quaternary phosphonium fluorides: Reagents for simple asymmetric nucleophilic fluorination reactions
Beaumont,Kiely,Rooney
, p. 47 - 50 (2007/10/03)
The novel chiral quaternary salt (RP)-benzylmenthylmethylphenylphosphonium fluoride was synthesised. The compound was used in the asymmetric nucleophilic fluorination of 2-bromopropiophenone to give 2-fluoropropiophenone in a 35% yield with [α]D20 = +1.94°.
