43083-13-2

Basic information

• Product Name: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• Synonyms: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;3-Cyano-2-hydroxy-6-phenylpyridine;2-keto-6-phenyl-1H-pyridine-3-carbonitrile;2-oxo-6-phenyl-1H-pyridine-3-carbonitrile;2-Hydroxy-6-phenylpyridine-3-carbonitrile;2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 43083-13-2
• Molecular Formula: C₁₂H₈N₂O
• Molecular Weight: 196.2
• Mol File: 43083-13-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 353-355°
• Boiling Point: 437°Cat760mmHg
• Flash Point: 218.1°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 7.74E-08mmHg at 25°C
• Refractive Index: 1.636
• PKA: 7.73±0.10(Predicted)
• CAS DataBase Reference: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(43083-13-2)
• EPA Substance Registry System: 2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE(43083-13-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 43083-13-2(Hazardous Substances Data)

Usage

General Description

2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile is a chemical compound with the molecular formula C14H10N2O. It belongs to the category of organic compounds known as phenylpyridines, which are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond. This chemical is not widely discussed in literature, thus information on its applications or uses is not readily available. However, it might find uses in pharmaceutical or chemical research due to its structural properties. As with most chemicals, proper safety measures should be observed in handling 2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile to protect from potential hazards.

InChI:InChI=1/C12H8N2O/c13-8-10-6-7-11(14-12(10)15)9-4-2-1-3-5-9/h1-7H,(H,14,15)

Upstream product

• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 54818-68-7 2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide 
• 121017-78-5 5-Cyano-6-oxo-2-phenyl-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 98-86-2 acetophenone 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 107-91-5 cyanoacetic acid amide 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 42731-38-4 (2Z)-3-hydroxy-1-phenyl-2-propen-1-one sodium salt 
• 109-94-4 formic acid ethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 121017-84-3 5-cyano-6-oxo-2-phenyl-1,6-dihydropyridine-3-carboxylic acid 
• 41125-10-4 benzoylacetaldehyde sodium salt 

Downstream Products

• 339109-23-8 1-Methyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile 
• 85814-99-9 2-methoxy-6-phenylpyridine-3-carbonitrile 
• 56162-63-1 6-phenyl-2-hydroxypyridine-3-carboxylic acid 
• 43083-14-3 2-chloro-3-cyano-6-phenylpyridine 
• 85830-29-1 6-Phenyl-3-(1H-tetrazol-5-yl)-pyridin-2-ol 
• 30517-31-8 3-cyano-6-phenylpyrimidin-2-yl diisopropyl phosphate 
• 1242622-26-9 3-cyano-6-phenylpyridin-2-yl acetate 
• 30645-52-4 3-cyano-6-phenylpyridin-2-yl diethyl phosphate 
• 147269-02-1 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 147269-09-8 2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 296797-34-7 methyl 3-amino-6-phenylthieno[2,3-b]pyridine-2-carboxylate 
• 85815-18-5 2-Methoxy-6-phenyl-N-(1H-tetrazol-5-yl)-nicotinamide 
• 85815-17-4 2-Hydroxy-6-phenyl-N-(1H-tetrazol-5-yl)-nicotinamide 
• 85815-19-6 2-Chloro-6-phenyl-N-(1H-tetrazol-5-yl)-nicotinamide 

Relevant articles and documents

2-Chloro-3-cyano-6-phenylpyridine

The molecular structure of the title compound (2-chloro-6-phenylpyridine-3-carbonitrile, C12H7ClN2) is presented. The molecule is nearly planar. Despite strong substituent interactions, the aromaticity of the pyridine frag

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.