43087-79-2

Basic information

• Product Name: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one
• Synonyms: (4Z)-4-(2,3-Dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one; 4-(2,3-Dimethoxy-benzylidene)-2-phenyl-4H-oxazol-5-one; 5(4H)-Oxazolone, 4-[(2,3-dimethoxyphenyl)methylene]-2-phenyl-, (4Z)-
• CAS NO: 43087-79-2
• Molecular Formula: C₁₈H₁₅NO₄
• Molecular Weight: 309.316
• Mol File: 43087-79-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 445.2°C at 760 mmHg
• Flash Point: 190.9°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.04E-08mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(43087-79-2)
• EPA Substance Registry System: (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(43087-79-2)

Safety Data

• Hazardous Substances Data: 43087-79-2(Hazardous Substances Data)

Usage

Description

(4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one is a heterocyclic compound characterized by its unique structure that includes a 1,3-oxazol-5(4H)-one ring and a 2,3-dimethoxybenzylidene group. It belongs to the class of organic compounds known as oxazolones, which are recognized for their diverse biological activities. (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one may hold potential applications in the fields of pharmaceuticals and materials science due to its distinctive structural features and properties, attracting the interest of researchers for further exploration into its possible uses and characteristics.

Uses

Used in Pharmaceutical Applications:
(4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one is used as a potential active pharmaceutical ingredient for its diverse biological activities. Its unique structure may allow it to interact with various biological targets, making it a candidate for the development of new drugs.
Used in Materials Science:
In the field of materials science, (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one may be utilized as a component in the design and synthesis of novel materials with specific properties. Its incorporation into material systems could lead to advancements in areas such as polymer science, nanotechnology, and advanced materials development.
Used in Chemical Research:
As a compound with a complex structure, (4Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one is used as a subject of study in chemical research to better understand its properties, reactivity, and potential applications. This may include investigations into its synthesis, stability, and interactions with other molecules.

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
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Downstream Products

• 1357516-02-9 (Z)-4-(2,3-dimethoxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one 
• 83949-20-6 N^α-benzoyl-2,3-dimethoxydehydrophenylalanylglycine methyl ester 
• 98833-70-6 α-benzoylamino-2,3-dimethoxy-trans-cinnamic acid 
• 28095-48-9 2-amino-3-(2,3-dihydroxyphenyl)propanoic acid 

Relevant articles and documents

Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones

Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 12 (IC50 = 28.90 ± 1.10 μM), 24 (IC50 = 31.4 ± 2.15 μM), 13 (IC50 = 35.0 ± 3.18 μM), 16 (IC50 = 35.0 ± 3.13 μM), and 25 (IC50 = 35.0 ± 3.18μM) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 ± 3.36, 57.8 ± 2.30, 57.72 ± 5.02, 56.18 ± 4.40, 57.85 ± 2.25, 69.05 ± 6.20, 54.8 ± 1.50, and 57.8 ± 2.30 μM showed a moderate antileishmanial activities.