43087-91-8

Basic information

• Product Name: 2-Phenyl-5-benzothiazolamine
• Synonyms: 2-Phenyl-5-benzothiazolamine
• CAS NO: 43087-91-8
• Molecular Formula: C₁₃H₁₀N₂S
• Molecular Weight: 226.31
• Mol File: 43087-91-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 430.9°Cat760mmHg
• Flash Point: 214.4°C
• Appearance: /
• Density: 1.1861 (rough estimate)
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• CAS DataBase Reference: 2-Phenyl-5-benzothiazolamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-5-benzothiazolamine(43087-91-8)
• EPA Substance Registry System: 2-Phenyl-5-benzothiazolamine(43087-91-8)

Safety Data

• Hazardous Substances Data: 43087-91-8(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic by ingestion.Severe eye irritant. When heated to decomposition it emitsvery toxic fumes of NOx and SOx.

InChI:InChI=1/C13H10N2S/c14-10-6-7-12-11(8-10)15-13(16-12)9-4-2-1-3-5-9/h1-8H,14H2

Upstream product

• 35539-24-3 S-2,4-dinitrophenyl thiobenzoate 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 4826-02-2 6-nitro-3-phenyl-1-(toluene-4-sulfonylamino)-1λ⁴-benzo[1,2,4]thiadiazine 
• 98-88-4 benzoyl chloride 
• 205827-96-9 N-(2-chloro-5-nitro-phenyl)-benzamide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 21715-13-9 2,4-diaminobenzenethiol 
• 65-85-0 benzoic acid 
• 16239-26-2 N-3-nitrophenylbenzamidine 
• 857950-75-5 bis-(4-acetylamino-2-amino-phenyl)-disulfide 
• 74804-14-1 bis(4-acetylamino-2-nitrophenyl) disulphide 
• 5540-60-3 N-(4-chloro-3-nitrophenyl)acetamide 
• 860521-46-6 thiobenzoic acid-(3-nitro-anilide) 
• 4771-08-8 N-(3-nitrophenyl)benzamide 

Downstream Products

• 1346678-91-8 2-{(E)-[(2-phenyl-1,3-benzothiazol-5-yl)imino]methyl}benzene-1,4-diol 
• 13399-20-7 2,7-diphenyl-benzo[1,2-d;3,4-d']bisthiazole 

Relevant articles and documents

Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis

A previous publication from this lab (Patrick, et al. Bioorg. Med. Chem. 2016, 24, 2451-2465) explored the antitrypanosomal activities of novel derivatives of 2-(2-benzamido)ethyl-4-phenylthiazole (1), which had been identified as a hit against Trypanosoma brucei, the causative agent of human African trypanosomiasis. While a number of these compounds, particularly the urea analogues, were quite potent, these molecules as a whole exhibited poor metabolic stability. The present work describes the synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on the molecule. The most promising compounds were the urea derivatives of 2-aryl-benzothiazol-5-amines. One such analogue, (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole (57) was chosen for in vivo efficacy studies based upon in vitro activity, metabolic stability, and brain penetration. This compound attained 5/5 cures in murine models of both early and late stage human African trypanosomiasis, representing a new lead for the development of drugs to combat this neglected disease.

New schiff bases derived from 2,5-dihydroxybenzaldehyde and amino-substituted 2-phenyl-1,3-benzothiazoles. Mesogenic monomers for liquid crystalline polyethers

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Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production

Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I): in which:G1 and G2 are hydrogen, halogen, hydroxyl, C1-C4 alkoxy, C1-C4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G1 or G2 is an amidino substituent of formula Q: and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring; andZ is an aryl or heteroaryl group, a linear or branched C1-C6 alkyl or alkenyl chain, a C1-C4 alkyl-aryl group or a C1-C4 alkyl-heteroaryl group.