43171-49-9

Basic information

• Product Name: 2,4'-Dichlorobenzhydrol
• Synonyms: 2,4'-Dichlorobenzhydrol;α-(2-Chlorophenyl)-4-chlorobenzenemethanol
• CAS NO: 43171-49-9
• Molecular Formula: C₁₃H₁₀Cl₂O
• Molecular Weight: 253.1239
• Mol File: 43171-49-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 378.1°Cat760mmHg
• Flash Point: 143.5°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 2.17E-06mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2,4'-Dichlorobenzhydrol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4'-Dichlorobenzhydrol(43171-49-9)
• EPA Substance Registry System: 2,4'-Dichlorobenzhydrol(43171-49-9)

Safety Data

• Hazardous Substances Data: 43171-49-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 83, p. 429, 1961 DOI: 10.1021/ja01463a042

InChI:InChI=1/C13H10Cl2O/c14-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)15/h1-8,13,16H

Upstream product

• 85-29-0 2,4'-dichlorobenzophenone 
• 36692-27-0 2-chlorophenylmagnesium bromide 
• 104-88-1 4-chlorobenzaldehyde 
• 106-39-8 bromochlorobenzene 
• 89-98-5 2-chloro-benzaldehyde 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 90155-46-7 1R,2R-trans-diphenyl-1,2-ethanediamine 

Downstream Products

• 508211-40-3 methyl 2-[(2-chlorophenyl)(4'-chlorophenyl)methoxy]-5-nitrobenzoate 
• 791119-48-7 1-benzyl-4-(2,4'-dichlorobenzhydryloxy)piperidine 
• 791118-70-2 3-[(2-chlorophenyl)-(4-chlorophenyl)-methoxy]-azetidine-1-carbonyl chloride 
• 1026410-64-9 [3(2,4'-dichlorobenzhydryloxy)azetidin-1-yl]piperidin-1-ylmethanone 
• 1404054-63-2 (2-chlorophenyl)(4-chlorophenyl)methyl (R)-quinuclidin-3-ylcarbamate 
• 1404054-64-3 (3R)-3-(((2-chlorophenyl)(4-chlorophenyl)methoxy)-carbonylamino)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo-[2.2.2]octane chloride 
• 1404055-01-1 (2-chlorophenyl)(4-chlorophenyl)methyl quinuclidine-3-carboxylate 
• 1404055-03-3 3-(((2-chlorophenyl)(4-chlorophenyl)methoxy)-carbonyl)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 61023-86-7 2,4'-dichlorodiphenyl bromomethane 
• 232599-13-2 1-benzhydryl-3-[bis(4-chlorophenyl)-methoxy]-azetidine 
• 791118-68-8 1-benzhydryl-3-[(2-chlorophenyl)-(4-chlorophenyl)-methoxy]-azetidine 
• 93535-56-9 Methoxy-(2-chlor-phenyl)-(4-chlor-phenyl)-methan 
• 96581-30-5 1,2-Bis-(2-chlor-phenyl)-1,2-bis-(4-chlor-phenyl)-ethan 
• 34113-46-7 1-(2-chlorophenyl)-1-(4-chlorophenyl)acetic acid 

Relevant articles and documents

Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones

We report here the discovery of a novel ketoreductase (KRED), named KmCR2, with a broad substrate spectrum on bioreduction of sterically bulky diaryl- and aryl(heteroaryl)methanones. The position of the substituent on aromatic rings (meta versus para or ortho) was revealed to control the stereospecificity of KmCR2. The stereoselective preparation of both enantiomers of diaryl- or aryl(heteroaryl)methanols using strategically engineered substrates with a traceless directing group (bromo group) showcased the potential application of this substrate-controlled bioreduction reaction. The combined use of substrate engineering and protein engineering, was demonstrated to be a useful strategy in efficiently improving stereoselectivity or switching stereopreference of enzymatic processes. (Figure presented.).

Synthesis and anticonvulsant activity of some cinnamylpiperazine derivatives

A series of cinnamylpiperazine derivatives was synthesized using different benzophenone as starting material. The structures of the compounds were proved by their IR, 1H-NMR spectroscopic data and mass spectra data. The anticonvulsant activities of these compounds were evaluated with maximal electroshock (MES) test and rotarod test with intraperitoneal injection on KunMing mice. Among all the flunarizine analogues, no one exhibited better anticonvulsant activity than flunarizine. Flunarizine (4i) exhibited anticonvulsant activity with ED50 of 38.1 mg/kg, TD50 of 164.3 mg/kg and PI of 4.3 through administration intraperitoneal, and with ED50 of 56.8 mg/kg, TD50 of 456.3 mg/kg and PI of 8.0 through oral administration.

Convenient synthesis of structurally novel 1,3-disubstituted azetidine derivatives

A convenient synthesis of structurally novel 1,3-disubstituted azetidine derivatives is described. The approach involves condensation of an azetidine building block with sulfonylated carbamic acid methyl ester, subsequently followed by quenching the imidoyl chloride with amines. Different derivatives were prepared by substituting benzhydrol as well as benzenesulfonamide as part of the core structure. Copyright Taylor & Francis Group, LLC.