43179-48-2Relevant articles and documents
Synthesis of Anemoclemosides A and B, Two Saponins Isolated from Anemoclema glaucifolium
Bouillon, Marc E.,Bertocco, Katia,Bischoff, Laura,Buri, Michelle,Davies, Lucy R.,Wilkinson, Elizabeth J.,Lahmann, Martina
supporting information, p. 7470 - 7473 (2020/12/01)
Steroidal and triterpenoid saponins are attractive for their wide-ranging pharmacological properties. The triterpenoid saponins Anemoclemoside A and B are root constituents of the Chinese folk medicinal plant Anemoclema glaucifolium (Ranunculaceae). Both
The first convergent total synthesis of penarolide sulfate A2, a novel α-glucosidase inhibitor
Gao, Yangguang,Shan, Qiuli,Liu, Jun,Wang, Linlin,Du, Yuguo
, p. 2071 - 2079 (2014/03/21)
Penarolide sulfate A2, a 31-membered macrolide encompassing a proline residue and three sulfate groups, was firstly synthesized in 16 linear steps with 4.8% overall yield. Three consecutive stereogenic centers in penarolide sulfate A2 were efficiently derived from natural chiral template l-arabinose. The crucial assembly reactions included Brown asymmetric allylation, olefin cross-metathesis, alkyne-epoxide coupling, and macrolactamization. The anti-yeast α-glucosidase activities of penarolide sulfate A2 and its fully desulfated derivative were examined showing IC50 values of 4.87 and 10.74 μg mL-1, respectively.
Synthesis of substituted imidazolo[1,2-α]piperidinoses and their evaluation as glycosidase inhibitors
Dubost, Estelle,Le Nouen, Didier,Streith, Jacques,Tarnus, Celine,Tschamber, Theophile
, p. 610 - 626 (2007/10/03)
The synthesis of substituted imidazolo[1,2-α]-L-arabino-piperidinoses is reported. The substituents are methyl, phenylmethyl, phenylethyl, cyclohexylethyl, pyridinylethyl, piperidinylethyl, phenylpropyl and hydroxymethyl. All substituents are connected to