4318-37-0

Basic information

• Product Name: N-Methylhomopiperazine
• Synonyms: 1H-1,4-Diazepine, hexahydro-1-methyl-;1-METHYLHOMOPIPERAZINE;1-METHYL-1,4-DIAZEPANE;1-METHYL-1,4-PERHYDRODIAZEPINE;HEXAHYDRO-1-METHYL-1H-1,4-DIAZEPINE;N-METHYLHOMOPIPERAZINE;MHPRZ;N-METHYL-1,4-DIAZACYCLOHEPTANE
• CAS NO: 4318-37-0
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.19
• EINECS: 1592732-453-0
• Product Categories: Amines and Anilines;Heterocycles
• Mol File: 4318-37-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 74-75 °C35 mm Hg(lit.)
• Flash Point: 113 °F
• Appearance: /
• Density: 0.918 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.761mmHg at 25°C
• Refractive Index: n20/D 1.477(lit.)
• Storage Temp.: -20°C
• PKA: 10.82±0.20(Predicted)
• CAS DataBase Reference: N-Methylhomopiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methylhomopiperazine(4318-37-0)
• EPA Substance Registry System: N-Methylhomopiperazine(4318-37-0)

Safety Data

• Hazard Codes: C
• Statements: 10-22-34
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• HazardClass: 4.1
• PackingGroup: II
• Hazardous Substances Data: 4318-37-0(Hazardous Substances Data)

Usage

Description

N-Methylhomopiperazine, also known as 1-Methylhomopiperazine, is an organic compound that is a colorless liquid. It is known for undergoing coupling reactions with a series of diazonium salts to produce various derivatives with potential pharmacological activities.

Uses

Used in Pharmaceutical Industry:
N-Methylhomopiperazine is used as a synthetic building block for the creation of novel benzimidazole derivatives, which possess pharmacological activities. These derivatives have potential applications in the development of new drugs and therapies.
Used in Chemical Research:
N-Methylhomopiperazine is used as a precursor in the synthesis of platinum(II) substituted disulfide complexes. These complexes are of interest in chemical research due to their unique properties and potential applications in various fields.
Used in Synthesis of 4-Methyl-1-[2-aryl-1-diazenyl]-1,4-diazepanes:
N-Methylhomopiperazine is used as a reactant in coupling reactions with diazonium salts to afford the 4-methyl-1-[2-aryl-1-diazenyl]-1,4-diazepanes, which are compounds with potential applications in various industries, including pharmaceuticals and materials science.

InChI:InChI=1/C6H14N2/c1-8-5-2-3-7-4-6-8/h7H,2-6H2,1H3

Upstream product

• 1046832-15-8 N-methylhomopiperazine dihydrochloride 
• 38956-79-5 3-hydrazinyl-6-methylpyridazine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 34508-82-2 monomethylethanolaminopropionitrile 
• 33759-44-3 3-<(2-hydroxyethyl)amino>propionitrile 
• 41999-70-6 N-(2-hydroxyethyl)-N-methyl-1,3-propanediamine 
• 5441-40-7 1-methyl-1,4-diazepan-5-one 

Downstream Products

• 99868-86-7 4-methyl-hexahydro-[1,4]diazepine-1-sulfonic acid diethylamide 
• 848-53-3 Homochlorcyclizine 
• 18739-40-7 4-methyl-hexahydro-[1,4]diazepine-1-carboxylic acid ethyl ester 
• 105788-46-3 4-methyl-hexahydro-[1,4]diazepine-1-carboxylic acid anilide 
• 63574-76-5 4-methyl-hexahydro-[1,4]diazepine-1-carboxylic acid diethylamide 
• 101953-62-2 2-(4-methyl-1-homopiperazino)-1H-benzimidazole 
• 95893-91-7 2-<(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl>-1H-benzimidazole 
• 85926-09-6 1-Methyl-4-(9H-xanthen-9-yl)-[1,4]diazepane 
• 86010-42-6 1-methyl-4-(3,4,5-trimethoxyphenylacetyl)perhydro-1,4-diazepine 
• 129572-40-3 Benzo[4,5]thieno[2,3-c]pyridin-3-yl-(4-methyl-[1,4]diazepan-1-yl)-methanone; hydrochloride 
• 98984-46-4 {5-[1-(4-Methyl-[1,4]diazepan-1-yl)-meth-(E)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid 
• 129841-32-3 4-(2-Hydroxy-5-methoxy-phenyl)-1-(4-methyl-[1,4]diazepan-1-yl)-4-phenyl-butan-1-one; hydrochloride 
• 82419-59-8 8-Fluoro-3-methyl-9-(4-methyl-[1,4]diazepan-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 140660-90-8 (4S,5S)-4-Cyclohexylmethyl-2,2-dimethyl-5-[(S)-3-methyl-2-(4-methyl-[1,4]diazepane-1-carbonyl)-butyl]-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

GPR139 RECEPTOR MODULATORS

Compounds are provided that modulate the GPR139 receptor, compositions containing the same, and to methods of their preparation and use for treatment of a malcondition wherein modulation of the GPR139 receptor is medically indicated or beneficial. Such compounds have the structure of Formula (X) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, R3, R4, R9, R10, R11, and R12, Q5, Q6, Q7 and Q8 are as defined herein.

A BEt3-Base Catalyst for Amide Reduction with Silane

Reported herein is the development of a simple but practical catalytic system for the selective reduction of amides with hydrosilane or hydrosiloxane. Low-cost and readily available triethylborane (1.0 M in THF), in combination with a catalytic amount of an alkali metal base, was found to catalyze the reduction of all three amide classes (tertiary, secondary, and primary amides) to form amines under mild conditions. In addition, the selective transformation of secondary amides to aldimines and primary amides to nitriles can also be achieved by using a proper combination of BEt3 and base. The scope of these BEt3-base-catalyzed amide hydrosilylation reactions has been explored in depth. Preliminary results of mechanistic studies suggest a modified Piers' silane Si-H···B activation mode wherein the hydride abstraction by BEt3 is promoted by the coordination of an alkoxide or hydroxide anion to the Si center.

14-substituted marcfortines and derivatives useful as antiparasitic agents

There are disclosed 14α-hydroxymarcfortine derivatives of the natural products marcfortine A, B, C, and D useful in the treatment and prevention of helminth and arthropod infections of animals and plants. The synthetic derivatives are of Formula (I). STR1