431947-09-0Relevant articles and documents
Synthesis of 7-azabicyclo[2.2.1]heptane derivatives via bridgehead radicals
Avenoza, Alberto,Busto, Jesús H,Cativiela, Carlos,Peregrina, Jesús M
, p. 1193 - 1197 (2002)
This report shows the versatility and synthetic potential of 7-azabicyclo[2.2.1]heptane-1-carboxylic acid (Ahc) to obtain several bridgehead 1-substituted-7-azabicyclo[2.2.1]heptane derivatives, including halogen derivatives, via bridgehead radical reactions, proving the existence of the bridgehead radical in 7-azabicyclo[2.2.1]heptane systems. Moreover, we have obtained the interesting compound N-benzoyl-7-azabicyclo[2.2.1]heptane, a precursor of epibatidine.