4320-30-3 Usage
Description
L-Arginine L-glutamate, also known as Modumate, is a white powder substance with the brand name Modumate (Abbott). It is a combination of two amino acids, L-arginine and L-glutamate, which play essential roles in various biological processes.
Uses
Used in Liver Support Applications:
L-Arginine L-glutamate is used as an intravenous ammonia detoxicant for the treatment of patients with liver failure. It helps in the detoxification process by reducing the levels of ammonia in the blood, which can be harmful in cases of liver dysfunction.
Used in Wound Healing Applications:
L-Arginine L-glutamate is used as a component in the making of an arginine glutamate solution for the healing of radiation-induced skin ulcers in guinea pigs. The amino acids in the solution promote wound healing by enhancing the immune response, increasing collagen synthesis, and improving the overall health of the skin.
Originator
Modamate,Abbott,US,1960
Manufacturing Process
This salt may be prepared by mixing L-arginine with L-glutamic acid in water
and crystallizing the resulting salt from the water by the addition of a polar
water miscible organic solvent to the water. For instance, when 17.2 g of Larginine
and 14.5 g of L-glutamic acid were dissolved in 155 g of water, a
clear homogeneous solution resulted which had a pH of 5.3. This solution was
filtered and the filtrate was evaporated at 50°C under reduced pressure to a
solution having a solids content of about 45%. Absolute methanol (220 g) was
added to the concentrated solution of the salt and this mixture cooled to 5°C
for one hour. The resulting solid salt was removed from the mixture by
filtration and washed with absolute methanol. After being dried preliminarily in
the air, the salt was further dried in a vacuum oven at 60°C for 3 hours. The
resulting salt, L-arginine-L-glutamate, weighed 30 g (94.6% of the
theoretically possible yield based on the amount of L-arginine and L-glutamic
acid employed) and melted at 193-194.5°C with decomposition.
Therapeutic Function
Ammonia detoxicant (hepatic failure)
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
A dipeptide; hence an amide.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Arginine L-glutamate emits toxic fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 4320-30-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,2 and 0 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4320-30:
(6*4)+(5*3)+(4*2)+(3*0)+(2*3)+(1*0)=53
53 % 10 = 3
So 4320-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H14N4O2.C5H9NO4/c7-4(5(11)12)2-1-3-10-6(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);3H,1-2,6H2,(H,7,8)(H,9,10)/t4-;3-/m00/s1
