43212-41-5 Usage
Description
2,4-Dichloro-6-methoxypyrimidine is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes two chlorine atoms at the 2nd and 4th positions, a methoxy group at the 6th position, and a pyrimidine ring. This structure endows it with unique properties that make it valuable in the development of certain drugs.
Uses
Used in Pharmaceutical Industry:
2,4-Dichloro-6-methoxypyrimidine is used as a chemical intermediate for the preparation of piperazinyl pyrimidine derivatives. These derivatives act as γ-secretase modulators, which are important in the treatment of various neurodegenerative diseases, such as Alzheimer's disease. 2,4-Dichloro-6-methoxypyrimidine's role in the synthesis of these modulators is crucial for developing effective therapies against such conditions.
Additionally, 2,4-Dichloro-6-methoxypyrimidine is used in the synthesis of α-azinylalkylamino-substituted (thiazolylamino)pyrimidines and -pyrazines. These compounds are selective JAK2 inhibitors, which have potential applications in the treatment of various inflammatory and autoimmune diseases, as well as certain types of cancer. 2,4-Dichloro-6-methoxypyrimidine's involvement in the creation of these inhibitors highlights its significance in the development of targeted therapies for a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 43212-41-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,2,1 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 43212-41:
(7*4)+(6*3)+(5*2)+(4*1)+(3*2)+(2*4)+(1*1)=75
75 % 10 = 5
So 43212-41-5 is a valid CAS Registry Number.
43212-41-5Relevant articles and documents
HEPATITIS B VIRAL ASSEMBLY EFFECTORS
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Paragraph 00162, (2016/10/31)
Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
Development of an efficient, scalable route for the preparation of a novel insulin-like growth factor-1 receptor modulator
Kumar, C.H. Vinod,Kavitake, Santosh,Kumar, Sythana Suresh,Cornwall, Philip,Ashok, Mithun,Bhagat, Sagar,Manjunatha, Sulur G.,Nambiar, Sudhir
, p. 1416 - 1421 (2012/10/29)
A chromatography-free and efficient synthesis of insulin-like growth factor-1 receptor (IGF-1R) modulator is reported. Herein we describe an improved synthesis for the target compound, which features facile introduction of a novel pyrrolidinyl-pyrimidyl isoxazole 8, via in situ sulfone displacement by fluorine. The overall process consists of six chemical steps and five isolations, with introduction of the expensive triheterocyclic unit 8 towards the end of the synthesis.
AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
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Page/Page column 57-58, (2009/01/20)
The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.