43216-28-0

Basic information

• Product Name: benzyl 2-bromohexanoate
• Synonyms: benzyl 2-bromohexanoate
• CAS NO: 43216-28-0
• Molecular Weight: 285.181
• Mol File: 43216-28-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl 2-bromohexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-bromohexanoate(43216-28-0)
• EPA Substance Registry System: benzyl 2-bromohexanoate(43216-28-0)

Safety Data

• Hazardous Substances Data: 43216-28-0(Hazardous Substances Data)

Upstream product

• 616-05-7 2-bromohexanoic acid 
• 100-51-6 benzyl alcohol 
• 142-62-1 hexanoic acid 
• 42768-46-7 2-bromohexanoyl chloride 
• 142-61-0 Hexanoyl chloride 

Downstream Products

• 6938-45-0 benzyl hexanoate 

Relevant articles and documents

Method for hydrogenolysis of halides

The invention discloses a method for hydrogenolysis of halides. The invention discloses a preparation method of a compound represented by a formula I. The preparation method comprises the following step: in a polar aprotic solvent, zinc, H2O and a compound represented by a formula II are subjected to a reaction as shown in the specification, wherein X is halogen; Y is -CHRR or R; hydrogenin H2O exists in the form of natural abundance or non-natural abundance. According to the preparation method, halide hydrogenolysis can be simply, conveniently and efficiently achieved through a simple and mild reaction system, and good functional group compatibility and substrate universality are achieved.

Cobalt-bisoxazoline-catalyzed asymmetric kumada cross-coupling of racemic α-bromo esters with aryl grignard reagents

The first cobalt-catalyzed asymmetric Kumada cross-coupling with high enantioselectivity has been developed. The reaction affords a unique strategy for the enantioselective arylation of α-bromo esters catalyzed by a cobalt-bisoxazoline complex. A variety of chiral α-arylalkanoic esters were prepared in excellent enantioselectivity and yield (up to 97% ee and 96% yield). The arylated products were transformed into α-arylcarboxylic acids and primary alcohols without erosion of ee. The new enantioenriched α-arylpropionic esters synthesized herein are potentially useful in the development of nonsteroidal anti-inflammatory drugs. This method was conducted on gram-scale and applied to the synthesis of highly enantioenriched (S)-fenoprofen and (S)-ar-turmerone.