432550-81-7

Basic information

• Product Name: 3-benzoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one
• Synonyms: 3-benzoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one
• CAS NO: 432550-81-7
• Molecular Weight: 451.641
• Mol File: 432550-81-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-benzoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one(432550-81-7)
• EPA Substance Registry System: 3-benzoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one(432550-81-7)

Safety Data

• Hazardous Substances Data: 432550-81-7(Hazardous Substances Data)

Upstream product

• 329729-35-3 3-Amino-2-[(S)-1-hydroxy-2-methylpropyl]quinazolin-4(3H)-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 626-56-2 3-Methylpiperidine 
• 432550-82-8 N-benzoyl-N-ethanoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one 
• 109-05-7 2-Methylpiperidin 
• 98-88-4 benzoyl chloride 
• 262600-86-2 (S)-3-Amino-2-(1-tert-butyldimethylsilyloxy-2-methylpropyl)quinazolin-4(3H)-one 

Downstream Products

• 20826-48-6 (R)-N-(1-phenylethyl)benzamide 
• 3480-59-9 (S)-N-(1-phenylethyl)benzamide 
• 432550-82-8 N-benzoyl-N-ethanoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one 

Relevant articles and documents

3-(N,N-diacylamino)quinazolin-4(3H)-ones as enantioselective acylating agents for amines

The presence of an N-N chiral axis in a 3-(N-benzoyl-N- isobutanoyl)aminoquinazolin-4(3H)-one (DAQ) bearing a chiral substituent in the 2-position of the quinazolinone allows separation of two enantiopure diastereoisomers; one of these diastereoisomers reacts with racemic 2- methylpiperidine to give (R)(+)-1-benzoyl-2-methylpiperidine (95% ee) and (S)-2-methylpiperidine (91% ee) even using stoichiometric quantities of reagents (1 equiv. DAQ: 2 equiv. amine). (C) 2000 Elsevier Science Ltd.