433709-05-8

Basic information

• Product Name: 2-chloro-N-[2-oxo-3-(1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphosphinan-2-yl]-acetamide
• CAS NO: 433709-05-8
• Molecular Weight: 316.724
• Mol File: 433709-05-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-[2-oxo-3-(1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphosphinan-2-yl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[2-oxo-3-(1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphosphinan-2-yl]-acetamide(433709-05-8)
• EPA Substance Registry System: 2-chloro-N-[2-oxo-3-(1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphosphinan-2-yl]-acetamide(433709-05-8)

Safety Data

• Hazardous Substances Data: 433709-05-8(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 113531-09-2 2-chloro-3-[(S)-α-methylbenzyl]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide 
• 128218-35-9 3-<(1-phenylethyl)amino>propanol 

Downstream Products

• 433709-06-9 C₁₃H₁₈⁽²⁾H₂ClN₂O₂P 

Relevant articles and documents

Studies on the side-chain hydroxylation of ifosfamide and its bromo analogue

Deutero-substituted (α,α,α′,α′-tetradeuterated) derivatives of ifosfamide (IF-d4) and its bromo analogue were synthesised. In vitro metabolic studies showed that microsomal hydroxylation of IF-d4 is slower than for unlabelled compound, suggesting that kinetic isotope effect operates during those transformations. At the same time deutero-substituted derivatives are more active against L1210 leukaemia in mice than unlabelled compounds, suggesting a negative role of side-chain hydroxylation metabolic pathways in the anticancer activity of ifosfamide and its analogues.