434-75-3 Usage
Description
2-Chloro-6-fluorobenzoic acid is an organic compound characterized by the presence of a chlorine atom at the 2nd position and a fluorine atom at the 6th position on a benzene ring, with a carboxylic acid group attached. It is a white crystalline solid that serves as a key intermediate in the synthesis of various organic compounds and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
2-Chloro-6-fluorobenzoic acid is used as a versatile reactant for the synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling with aryl iodides. This process is crucial in the development of pharmaceutical compounds, as biaryls are common structural motifs in many bioactive molecules and drug candidates.
Used in Fluorinated Biaryls and Heterobiaryls Synthesis:
In the field of organic chemistry, 2-Chloro-6-fluorobenzoic acid is utilized in the preparation of fluorinated biaryls and heterobiaryls. This is achieved through copper-catalyzed decarboxylative cross-coupling of aryl and heteroaryl iodides or bromides with potassium polyfluorobenzoates. The resulting fluorinated biaryls and heterobiaryls are valuable building blocks for the synthesis of complex organic molecules and have potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Overall, 2-Chloro-6-fluorobenzoic acid plays a significant role in the synthesis of various organic compounds and pharmaceuticals, making it an important chemical intermediate in the chemical and pharmaceutical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 434-75-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,3 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 434-75:
(5*4)+(4*3)+(3*4)+(2*7)+(1*5)=63
63 % 10 = 3
So 434-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClFO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11)
434-75-3Relevant articles and documents
RORγ MODULATORS
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Page/Page column 47-48, (2018/04/13)
The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.
An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim]HSO4 Dedicated to my mentor Professor (Mrs.) Krishna Misra on her 76th birthday
Kumar, Satyanand,Dixit, Sandeep Kumar,Awasthi, Satish Kumar
supporting information, p. 3802 - 3804 (2014/07/07)
Environmentally benign ionic liquid [bmim]HSO4 was found suitable for conversion of nitriles into carboxylic acids under mild conditions with excellent purity.
Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes
Mongin, Florence,Schlosser, Manfred
, p. 6551 - 6554 (2007/10/03)
Deprotonation of fluoroarenes carrying chlorine or bromine as additional substituents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide.
