4341-76-8Relevant articles and documents
C-Alkylation of αβ-Acetylenic Esters using Electrochemically Generated Intermediates
Tokuda, Masao,Nishio, Osamu
, p. 188 - 189 (1980)
Electrolysis at a platinum cathode of ethyl alk-2-ynoates in the presence of an excess of alkyl iodide in hexamethylphosphoramide or dimethylformamide solution containing tetra-n-butylammonium iodide gave the corresponding non-conjugated dialkylation products, ethyl 2,2-dialkylalk-3-ynoates, in good yield.
One-pot mild and efficient synthesis of [1,3]thiazino[3,2-: A] indol-4-ones and their anti-proliferative activity
Rhodes, Steven,Short, Spencer,Sharma, Sidhika,Kaur, Ramneet,Jha, Mukund
supporting information, p. 3914 - 3920 (2019/04/30)
A base mediated environmentally benign one-pot efficient methodology has been developed for the synthesis of [1,3]thiazino[3,2-a]indol-4-ones using indoline-2-thiones and propiolate esters in aqueous medium. The conjugate addition of thiones first results in ethyl (3-(indol-2-yl)thio)acrylates in situ, which subsequently undergoes intramolecular cyclization to produce indole-fused thiazin-4-ones in good to excellent yields. The cytotoxic screening of the synthesized compounds using MTT assay revealed the anti-proliferative nature of these frameworks against triple negative breast cancer cell lines with the highest activity emanating from 4H-[1,3]thiazino[3,2-a]indol-4-one and 8-methyl-2-propyl-4H-[1,3]thiazino[3,2-a]indol-4-one compounds.
SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
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Paragraph 00303; page 125, (2014/08/19)
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
Selective one-pot synthesis of allenyl and alkynyl esters from β-ketoesters
Maity, Pradip,Lepore, Salvatore D.
body text, p. 158 - 162 (2009/04/07)
(Chemical Equation Presented) A convenient method is described for the dehydration of β-ketoesters to generate conjugated and deconjugated alkynyl esters and conjugated allenyl esters. This sequential one-pot method involves the formation of a vinyl trifl