4345-46-4

Basic information

• Product Name: Isoxazole, 3,5-dimethyl-4-phenyl-
• CAS NO: 4345-46-4
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Mol File: 4345-46-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Isoxazole, 3,5-dimethyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3,5-dimethyl-4-phenyl-(4345-46-4)
• EPA Substance Registry System: Isoxazole, 3,5-dimethyl-4-phenyl-(4345-46-4)

Safety Data

• Hazardous Substances Data: 4345-46-4(Hazardous Substances Data)

Upstream product

• 5910-25-8 3-phenylpentane-2,4-dione 
• 79-24-3 Nitroethane 
• 100-52-7 benzaldehyde 
• 832114-00-8 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole 
• 17958-94-0 Perfluoroctansulfonsaeure-phenylester 
• 108-86-1 bromobenzene 
• 16114-47-9 3,5-dimethylisoxazole-4-boronic acid 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 1160169-35-6 1-(3-methyl-2-phenyl-2H-azirin-2-yl)ethanone 
• 10558-25-5 4-bromo-3,5-dimethyl-1,2-oxazole 
• 98-80-6 phenylboronic acid 
• 98-13-5 Phenyltrichlorosilane 
• 100-51-6 benzyl alcohol 
• 2633-57-0 triallyl(phenyl)silane 

Downstream Products

• 14179-55-6 3-Phenylpentane-2,4-dione 

Relevant articles and documents

The direct C(sp2)-H functionalization and coupling of aromatic N-heterocycles with (hetero)aryl bromides by [PdX2(imidazolidin-2-ylidene)(Py)] catalysts

In this study, a series of air- and moisture-stable imidazolidin-2-ylidene-based new palladium complexes with the general formula [PdX2(NHC)(Py)] were synthesized (NHC = N-heterocyclic carbene, Py = pyridine, X = Cl or I). The structures of the

A Monophosphine Ligand Derived from Anthracene Photodimer: Synthetic Applications for Palladium-Catalyzed Coupling Reactions

Herein, we present an air-stable dianthracenyl monophosphine ligand (diAnthPhos) which can be prepared in two steps from commercially available anthracene derivatives. The ligand exhibits excellent efficiency for palladium-catalyzed coupling reactions. In particular, Miyaura borylation of heterocycle-containing electrophiles can be facilitated employing the diAnthPhos ligand with a broad substrate scope and low catalyst loading. The valuable synthetic utility of the new ligand is further demonstrated by a one-pot Miyaura borylation/Suzuki coupling protocol for heteroaryl-containing substrates.

Ni: Vs. Pd in Suzuki-Miyaura sp2-sp2 cross-coupling: A head-to-head study in a comparable precatalyst/ligand system

The Suzuki-Miyaura reaction is a cornerstone method for sp2-sp2 cross-coupling in industry. There has been a concerted effort to enable the use of Ni catalysis as an alternative to Pd in order to mitigate cost and improve sustainability. Despite significant advances, ligand development for Ni-catalyzed Suzuki-Miyaura cross-coupling remains underdeveloped when compared to Pd and, as a consequence, ligands for Ni-catalyzed processes are typically taken from the Pd arena. In this study we evaluate the effect of using a similar Ni and Pd precatalyst based on a common bidentate ligand (dppf) in a head-to-head format for the most common type of biaryl couplings, establishing the practical implications of direct replacement of Pd with Ni, and identifying the potential origins of these observations in a mechanistic context.