4347-18-6 Usage
General Description
4-oxo-L-proline, also known as pyrrolidone carboxylic acid or P5C, is a chemical compound that is a derivative of the amino acid proline. It is an important intermediate in the metabolism of proline and is involved in various biochemical pathways, including the proline cycle and the synthesis of collagen. 4-oxo-L-proline is also a precursor for the biosynthesis of the neurotransmitter gamma-aminobutyric acid (GABA). In addition, it has been studied for its potential role in the treatment of various diseases, including cancer and neurodegenerative disorders. Its versatile biological functions make it an important molecule in both basic biochemistry and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 4347-18-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,4 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4347-18:
(6*4)+(5*3)+(4*4)+(3*7)+(2*1)+(1*8)=86
86 % 10 = 6
So 4347-18-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h4,6H,1-2H2,(H,8,9)/t4-/m0/s1
4347-18-6Relevant articles and documents
Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles
Smart, Tristan J.,Hamed, Refaat B.,Claridge, Timothy D.W.,Schofield, Christopher J.
supporting information, (2019/11/26)
Studies on the substrate selectivity of recombinant ferrous-iron- and 2-oxoglutarate-dependent proline hydroxylases (PHs) reveal that they can catalyse the production of dihydroxylated 5-, 6-, and 7-membered ring products, and can accept bicyclic substrates. Ring-substituted substrate analogues (such hydroxylated and fluorinated prolines) are accepted in some cases. The results highlight the considerable, as yet largely untapped, potential for amino acid hydroxylases and other 2OG oxygenases in biocatalysis.
