4362-36-1

Basic information

• Product Name: 2-(2-chloroethyl)-1,3-dioxolane
• Synonyms: 2-(2-chloroethyl)-1,3-dioxolane
• CAS NO: 4362-36-1
• Molecular Formula: C5H9ClO2
• Molecular Weight: 136.57676
• EINECS: 224-450-4
• Mol File: 4362-36-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 179.6 °C at 760 mmHg
• Flash Point: 71.5 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 1.26mmHg at 25°C
• Refractive Index: 1.434
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2-chloroethyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloroethyl)-1,3-dioxolane(4362-36-1)
• EPA Substance Registry System: 2-(2-chloroethyl)-1,3-dioxolane(4362-36-1)

Safety Data

• Hazardous Substances Data: 4362-36-1(Hazardous Substances Data)

Usage

General Description

2-(2-chloroethyl)-1,3-dioxolane is a chemical compound that consists of a dioxolane ring with a 2-chloroethyl group attached to one of the carbon atoms. It is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. The 2-chloroethyl group makes this compound reactive and capable of forming covalent bonds with other molecules, which is useful in the production of drugs and pesticides. Additionally, the dioxolane ring contributes to the chemical's stability and solubility in various solvents. It is important to handle this compound with care, as the 2-chloroethyl group can be toxic and mutagenic if it comes into contact with living organisms. Overall, 2-(2-chloroethyl)-1,3-dioxolane is a versatile building block in chemical synthesis with both beneficial and potentially harmful properties.

InChI:InChI=1/C5H9ClO2/c6-2-1-5-7-3-4-8-5/h5H,1-4H2

Upstream product

• 107-21-1 ethylene glycol 
• 107-02-8 acrolein 
• 75-77-4 chloro-trimethyl-silane 
• 1269417-07-3 C₁₂H₁₄⁽²⁾HClO₃S 
• 1269417-06-2 C₁₂H₁₅ClO₃S 
• 1269417-05-1 C₁₂H₁₅ClO₃S 
• 35573-93-4 3-chloro-1,1-diethoxy-propane 

Downstream Products

• 5432-30-4 2-octyl-1,3-dioxolane 
• 6316-24-1 undecanal ethylene acetal 
• 79797-00-5 ((Z)-2-Pent-2-enyl)-[1,3]dioxolane 
• 5465-08-7 2-(β-Hydroxyethyl)-1,3-dioxolane 
• 83665-55-8 2-(2-iodoethyl)-1,3-dioxolane 
• 92971-91-0 β-(phenoxy)propionaldehyde ethylene acetal 
• 104821-38-7 2-(2-(4-(2-chloro-7-fluoro-10,11-dihydrodibenzothiepin-10-yl)piperazine-1-yl)ethyl)-1,3-dioxolane 
• 92971-92-1 β-(2-methoxyphenoxy)propionaldehyde ethylene acetal 
• 92971-94-3 β-(4-methoxyphenoxy)propionaldehyde ethylene acetal 
• 70931-49-6 1-(2-(1,3-dioxolan-2-yl)ethyl)-4-(7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin-11-yl)piperazine 
• 4388-58-3 β-cyanopropionaldehyde ethylene acetal 
• 92971-95-4 β-(3-benzyloxyphenoxy)propionaldehyde ethylene acetal 
• 92971-93-2 β-(3-methoxyphenoxy)propionaldehyde ethylene acetal 
• 247590-02-9 C₁₇H₁₉O₂P 

Relevant articles and documents

Iterative stereospecific reagent-controlled homologation using a functionalized α-chloroalkyllithium: Synthesis of cyclic targets related to epibatidine

Enantioenriched 1-chloro-2-(1,3-dioxolan-2-yl)ethyllithium was generated by PhLi initiated sulfoxide-ligand exchange and deployed in situ for sequential double stereospecific reagent-controlled homologation (StReCH) of B-(2-chloro-pyrid-5-yl) pinacol boronate. This process afforded highly functionalized contiguous stereodiad motifs (typically, % ee ≥ 98%, dr ≥ 85:15) amenable to subsequent annulative transformations as demonstrated by the concise synthesis (5-7 steps) of cyclic adducts related to the analgesic alkaloid epibatidine.

Preparation of [1,2,3,4,5-13C 5]-5-Amino-4-oxopentanoic Acid (ALA) - Design of a Synthetic Scheme to Prepare Any 13C- and 15N-Isotopomer with High Isotopic Enrichment

5-Amino-4-oxopentanoic acid (5-aminolevulinic acid) is a precursor in the biosynthesis of the biologically active porphyrins such as chlorophyll, bacteriochlorophyll, heme, etc. These systems are central in photosynthesis, oxygen transport, electron transport, etc. In this paper we describe a simple scheme to prepare any isotopomer of 5-aminolevulinic acid in a few steps in high yield. Using a similar scheme, levulinic acid can now also be prepared in any isotopomeric form. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

LES ORGANOSILICIQUES COMME AGENTS DE SYNTHESE D'ACETALS β-HALOGENES

The reactions of unsaturated aldehydes and ketones with diols in presence of halogenosilane lead to the synthesis of halogenoacetals in yields of 60-97percent.