4362-42-9

Basic information

• Product Name: 1,3-Dioxolane, 2-(1-chloro-1-methylethyl)-
• Synonyms: 1,3-Dioxolane, 2-(1-chloro-1-methylethyl)-
• CAS NO: 4362-42-9
• Molecular Formula: C6H11ClO2
• Molecular Weight: 150.6
• Mol File: 4362-42-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxolane, 2-(1-chloro-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(1-chloro-1-methylethyl)-(4362-42-9)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(1-chloro-1-methylethyl)-(4362-42-9)

Safety Data

• Hazardous Substances Data: 4362-42-9(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Uses

a. Solvent
b. Intermediate in the production of pharmaceuticals, agrochemicals, and other chemical compounds

Chemical classification

Ether

Structural features

a. Contains a chlorine atom
b. Contains a methyl group
c. Attached to a 1,3-dioxolane ring structure

Boiling point

110-113°C

Flammability

Flammable

Safety precautions

a. Handle and store according to proper safety protocols
b. Minimize risk of exposure and combustion

Upstream product

• 107-21-1 ethylene glycol 
• 68963-60-0 2-chloroisobutyraldehyde dimethyl acetal 

Relevant articles and documents

Identification, synthesis, and characterization of a unique class of N- methyl-D-aspartate antagonists. The 6,11-ethanobenzo[b]quinolizinium cation

A series of novel N-methyl-D-aspartate antagonists acting at the phencyclidine site has been identified. Compound 2 has a K(i) = 8 ± 1 nM (vs [3H]thienylcyclidine, [3H]TCP) as a mixture of enantiomers. Resolution and further testing indicate that (-)-2, K(i) = 4 ± 0.7 nM, is a potent and selective TCP site ligand with neuroprotective activity in cultured neurons in the presence of excitotoxic concentrations of NMDA (IC50 = 26 nM). Compound (-)-2 is > 1000-fold selective for the TCP site vs a panel of receptor types including opiate, adrenergic, serotonergic, dopamine, adenosine, dihydropyridine, and benzodiazepine and displays increased selectivity for the activated (open) NMDA receptor-ion channel complex vs PCP and MK801 as measured by patch recordings in cultured, voltage-clamped neurons. Highly enhanced 'open-channel' selectivity leads to tentative classification of these ligands as uncompetitive vs NMDA. Ligands with these characteristics may enable deconvolution of the pharmacologic effects associated with typical noncompetitive NMDA antagonists. We report here on the identification, synthesis, and activity of compounds of this structural class.