436848-01-0

Basic information

• Product Name: 4-bromo-1-(tert-butoxycarbonyloxy)benzene
• Synonyms: 4-bromo-1-(tert-butoxycarbonyloxy)benzene
• CAS NO: 436848-01-0
• Molecular Weight: 273.126
• Mol File: 436848-01-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-bromo-1-(tert-butoxycarbonyloxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-(tert-butoxycarbonyloxy)benzene(436848-01-0)
• EPA Substance Registry System: 4-bromo-1-(tert-butoxycarbonyloxy)benzene(436848-01-0)

Safety Data

• Hazardous Substances Data: 436848-01-0(Hazardous Substances Data)

Upstream product

• 1187442-17-6 tert-butyl 2,4-dibromophenyl carbonate 
• 106-41-2 4-bromo-phenol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 1333434-82-4 tert-butyl (4-(2-methylquinolin-8-yl)phenyl)carbonate 
• 106-41-2 4-bromo-phenol 

Relevant articles and documents

Facile tert-butoxycarbonylation of alcohols, phenols, and amines using BiCl3 as a mild and efficient catalyst

Facile tert-butoxycarbonylation of alcohols, phenols, and amines is described by treatment of alcohols, phenols, and amines with di-tert-butyl dicarbonate in the presence of a catalytic amount of bismuth(III) chloride, a mild and efficient catalyst, at room temperature in excellent yields. Copyright Taylor & Francis Group, LLC.

NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents

A cobalt-catalyzed cross-coupling between 3- and 4-iodopiperidines and Grignard reagents is disclosed. The reaction is an efficient, cheap, chemoselective, and flexible way to functionalize piperidines. This coupling was used as the key step to realize a short synthesis of (±)-preclamol. Some mechanistic investigations were conducted that highlight the formation of radical intermediates. Scaffold synthesis: A cobalt-catalyzed cross-coupling between iodopiperidines and Grignard reagents is reported (see scheme; PG=protecting group). A large variety of 3- and 4-substituted piperidines were synthesized and the method was applied to a short synthesis of (±)-preclamol. This work constitutes one of the rare examples of cross-couplings involving 3-halogeno piperidines.