4375-26-2Relevant articles and documents
Synthesis method of apronal
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Paragraph 0054-0060; 0076; 0077, (2019/12/11)
Belonging to the technical field of drug synthesis, the invention discloses a synthesis method of apronal. The method adopts commercial raw material isopropyl malonate diester as the starting raw material for reaction with allyl bromide or allyl chloride under an alkaline condition by one-pot process to generate dimethyl allyl isopropylmalonate, then hydrolysis is carried out to generate allyl isopropylmalonic acid, which is subjected to thermal decomposition to be further converted into acyl chloride for reaction with urea, thus obtaining apronal. The synthetic route adopted by the inventiononly needs two or three steps, the whole process is in simple in operation, the materials are easily available, the cost is low, and the yield is high, therefore the method is suitable for industrialproduction.
SUBSTITUTED OXOTREMORINE DERIVATIVES
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, (2008/06/13)
This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds. STR1
