4383-55-5

Basic information

• Product Name: 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester
• Synonyms: 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester
• CAS NO: 4383-55-5
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.65624
• Mol File: 4383-55-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester(4383-55-5)
• EPA Substance Registry System: 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester(4383-55-5)

Safety Data

• Hazardous Substances Data: 4383-55-5(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 876726-66-8 ethyl 3-hydroxy-2-diazo-3-(4-chlorophenyl)-propionate 

Downstream Products

• 34966-48-8 ethyl 2-(4-chlorophenyl)-2-oxoacetate 

Relevant articles and documents

DBU-catalyzed condensation of acyldiazomethanes to aldehydes in water and a new approach to ethyl β-hydroxy α-arylacrylates

DBU-catalyzed condensation of ethyl diazoacetate (EDA) with aldehydes in pure water afforded corresponding β-hydroxy α-diazo carbonyl compounds. The β-hydroxy group of the products was further converted into β-siloxy group. The Rh(II)-catalyzed reaction of the β-aryl β-siloxy α-diazo carbonyl compounds gave 1,2-aryl shift products predominantly. The three-step transformation constitutes an efficient synthesis of ethyl β-hydroxy α-arylacrylates.