438625-58-2 Usage
Description
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride (HMMA) is an analytical reference standard that belongs to the amphetamine class. It is a phase 2 metabolite of 3,4-MDMA, which is typically glucuronidated or sulfated before excretion and can be detected in urine after cleavage. Intact forms of HMMA may also be measured. 4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is primarily used for forensic and research purposes.
Uses
Used in Forensic Applications:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a forensic tool for the detection and identification of 3,4-MDMA metabolites in urine samples. Its application helps in the analysis of drug use and abuse cases, providing valuable information for legal and investigative processes.
Used in Research Applications:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a research compound for studying the metabolism, pharmacokinetics, and pharmacodynamics of 3,4-MDMA and its metabolites. This helps in understanding the mechanisms of action, potential side effects, and the development of new therapeutic strategies related to MDMA and its derivatives.
Used in Drug Metabolism Studies:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a reference standard in drug metabolism studies to investigate the metabolic pathways and enzyme interactions of 3,4-MDMA. This information is crucial for the development of new drugs, drug interactions, and the optimization of drug dosages.
Used in Toxicology:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a toxicological marker for assessing the presence and concentration of 3,4-MDMA metabolites in biological samples. This helps in determining the extent of drug exposure, potential toxicity, and the risk of adverse health effects.
Used in Drug Testing Laboratories:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a quality control material in drug testing laboratories to ensure the accuracy and reliability of analytical methods and instruments used for the detection and quantification of 3,4-MDMA and its metabolites in various biological matrices.
Used in Pharmaceutical Development:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a starting material or intermediate in the synthesis of new pharmaceutical compounds with potential therapeutic applications. Its structural properties can be exploited to design and develop novel drugs with improved efficacy and safety profiles.
Used in Analytical Chemistry:
4-Hydroxy-3-methoxy Methamphetamine Hydrochloride is used as a reference material in the development and validation of analytical methods for the detection and quantification of amphetamines and their metabolites in various samples, including biological, environmental, and forensic samples.
Check Digit Verification of cas no
The CAS Registry Mumber 438625-58-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,8,6,2 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 438625-58:
(8*4)+(7*3)+(6*8)+(5*6)+(4*2)+(3*5)+(2*5)+(1*8)=172
172 % 10 = 2
So 438625-58-2 is a valid CAS Registry Number.
438625-58-2Relevant articles and documents
4-Hydroxy-3-methoxymethamphetamine glucuronide as a phase II metabolite of 3,4-methylenedioxymethamphetamine: Enzyme-assisted synthesis and involvement of human hepatic uridine 5′-diphosphate-glucuronosyltransferase 2B15 in the glucuronidation
Shoda, Takuji,Fukuhara, Kiyoshi,Goda, Yukihiro,Okuda, Haruhiro
experimental part, p. 472 - 475 (2009/12/09)
3,4-Methylenedioxymethamphetamine (MDMA), one of the most popular illicit recreational drugs, is metabolized primarily into 4-hydroxy-3- methoxymethamphetamine (HMMA) by drug-metabolizing enzymes. HMMA is further metabolized by phase II enzymes to give th
Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites
Pizarro, Nieves,De la Torre, Rafael,Farre, Magi,Segura, Jordi,Llebaria, Amadeu,Joglar, Jesus
, p. 1085 - 1092 (2007/10/03)
Enantiomerically-enriched (S)-3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites (S)-4-hydroxy-3-methoxymethamphetamine (HMMA) and (S)-3,4-dihydroxymethamphetamine (HHMA) were prepared or unequivocal identification of the differential enantioselective metabolism of these compounds as well as for its application in the analysis of biological samples. Capillary electrophoresis with cyclodextrin derivatives and a chemical correlation of (S)-MDMA, (S)-HMMA and (S)-HHMA has been performed to assign the absolute stereochemistry of major isomers in analytical standards enriched with such enantiomers. Copyright
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