4392-36-3

Basic information

• Product Name: N-benzenesulfonylacetamidine
• Synonyms: N-benzenesulfonylacetamidine
• CAS NO: 4392-36-3
• Molecular Weight: 198.246
• Mol File: 4392-36-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzenesulfonylacetamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzenesulfonylacetamidine(4392-36-3)
• EPA Substance Registry System: N-benzenesulfonylacetamidine(4392-36-3)

Safety Data

• Hazardous Substances Data: 4392-36-3(Hazardous Substances Data)

Upstream product

• 938-10-3 phenylsulfonyl azide 
• 62-55-5 thioacetamide 
• 124-42-5 acetamidine hydrochloride 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Sulfonyl azides acylsulfonamide derivatives and their use for production of derivative.

PROBLEM TO BE SOLVED: To provide a click reaction having bioorthogonality and high versatility.SOLUTION: Sulfonyl amidines and acylsulfonamides are manufactured by using thioamide and sulfonyl azide. The reaction is a novel click reacting having no need of additives and bioorthogonality and high versatility with proceeding under a mild condition and in a solution.

Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase

New acetamidines structurally related to N-(3-(aminomethyl)benzyl) acetamidine (1, W1400) were designed as inhibitors of inducible nitric oxide synthase (iNOS). Six compounds were found to be selective for iNOS over endothelial nitric oxide synthase (eNOS), and among them, the most active and selective compound was the N-benzylacetamidine 2. A docking study was also performed to shed light on the effects of the structural modifications on the interaction of the designed inhibitors with the NOS.