4393-16-2

Basic information

• Product Name: 4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE
• Synonyms: 4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE;4-(Methylsulfonyl)benzylamine;4-MethylsulfonylbenzylamineHCl;4-METHYLSULPHONYLBENZYLAMINE HYDROCHLORIDE 95%;4-Methylsulphonylbenzylamine hydrochloride,95%;4-(Methylsulfonyl)Benzenemethanamine;4-(Methylsufonyl)benzylamine HCI;4-(Methanesulfonyl)benzylamine
• CAS NO: 4393-16-2
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 221.7
• Product Categories: Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 4393-16-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 269-277 °C
• Boiling Point: 370℃
• Flash Point: 178℃
• Appearance: Orange/Crystals or Crystalline Powder
• Density: 1.225
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE(4393-16-2)
• EPA Substance Registry System: 4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE(4393-16-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 24/25-26
• Hazardous Substances Data: 4393-16-2(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow-pink powder

InChI:InChI=1/C8H11NO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3/p+1

Upstream product

• 98593-51-2 4-(methylsulfonyl)benzylamine hydrochloride 
• 3185-99-7 Methyl p-tolyl sulfone 
• 15898-42-7 sodium 4-cyanobenzenesulfinate 
• 710-24-7 4-acetamidobenzenesulfinic acid 
• 5470-49-5 4-methanesulfonylphenylamine 
• 22821-80-3 N-(4-methanesulfonylphenyl)acetamide 
• 28073-51-0 4-(acetamidomethyl)benzene-1-sulfonyl chloride 
• 628297-98-3 4-(acetylamino-methyl)-benzenesulfinic acid 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 5661-48-3 N-(4-methanesulfonyl-benzyl)-acetamide 
• 53147-98-1 4-(methylsulfonyl)benzaldehyde oxime 

Downstream Products

• 1038409-81-2 C₁₇H₁₇ClN₂O₅S 
• 1038409-60-7 C₂₁H₁₈N₄O₃S 
• 1451993-47-7 C₁₇H₁₈N₄O₃S₂ 
• 229627-35-4 3-[(4-methanesulfonyl-benzyl)-({2-[3-methoxy-4-(3-o-tolylureido)phenyl]-acetylamino}-acetyl)-amino]propionic acid 
• 229630-34-6 3-{(4-methanesulphonyl-benzyl)-[({[3-methoxy-4-(3-o-tolylureido)phenyl]-acetyl}-N-methylamino)-acetyl]-amino}-propionic acid 
• 3571-02-6 α,α-Dichlor-N-(2-aethoxy-aethyl)-N-(4-methylsulfonyl-benzyl)-acetamid 
• 916673-05-7 4-Amino-6-ethoxy-5-((Z)-2-trimethylsilanyl-but-1-en-3-ynyl)-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide 

Relevant articles and documents

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Discovery of carbazole carboxamides as novel RORγt inverse agonists

A novel series of carbazole carboxamides was discovered as potent RORγt inverse agonists using a scaffold hybridization strategy. Structure-activity relationship exploration on the amide linker, carbazole ring and arylsulfone moiety of the hybrid amide 3a led to identification of potent RORγt inverse agonists. Compound 6c was found to have a good RORγt activity with an IC50 of 58.5 nM in FRET assay, and reasonable inhibitory activity in mouse Th17 cell differentiation assay (58.8% inhibition at 0.3 μM). The binding mode of carbazole carboxamides in RORγt ligand binding domain was discussed.