4393-72-0

Basic information

• Product Name: N(4)-desoxychlordiazepoxide
• Synonyms: N(4)-desoxychlordiazepoxide
• CAS NO: 4393-72-0
• Molecular Formula: C₁₆H₁₄ClN₃
• Molecular Weight: 283.75546
• Mol File: 4393-72-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 471.2°Cat760mmHg
• Flash Point: 238.8°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 4.75E-09mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: N(4)-desoxychlordiazepoxide(CAS DataBase Reference)
• NIST Chemistry Reference: N(4)-desoxychlordiazepoxide(4393-72-0)
• EPA Substance Registry System: N(4)-desoxychlordiazepoxide(4393-72-0)

Safety Data

• Hazardous Substances Data: 4393-72-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H14ClN3/c1-18-15-10-19-16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)20-15/h2-9H,10H2,1H3,(H,18,20)

Upstream product

• 1088-11-5 desmethyldiazepam 
• 74-89-5 methylamine 
• 4547-02-8 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione 

Downstream Products

• 819793-76-5 8?chloro?6?phenyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine 

Relevant articles and documents

Reactions of 1,4-benzodiazepinic N-nitrosoamidines with tosylmethyl isocyanide: A novel synthesis of midazolam

Reaction of 1,4-benzodiazepinic N-nitrosoamidines, used as synthetic equivalents of imidoyl chlorides, with the monoanion of tosylmethyl isocyanide is described. The process gives entry to 3-(4-tosyl)imidazo[1,5-a][1,4] benzodiazepines, compounds which have not been described yet in the literature. These systems can be derivatized to the corresponding trisubstituted 1,4-benzodiazepines by alkylation or acylation of the imidazole ring. These new heterocyclic derivatives are potentially useful in the field of medicinal chemistry. In addition, midazolam 3, the anesthetic properties of which are well established, can be easily prepared in one step by desulfonylation of compound 7a.