439811-20-8 Usage
General Description
(RS)-1-[4-(trifluoromethyl)phenyl]propylamine, also known as fluoxetine, is a common antidepressant medication that belongs to the class of selective serotonin reuptake inhibitors (SSRIs). It helps to alleviate symptoms of depression and other mood disorders by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that plays a crucial role in regulating mood, appetite, and sleep. This chemical is commonly prescribed to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, and other mental health conditions. It is typically taken orally in the form of capsules or tablets and may have potential side effects such as nausea, headaches, and changes in weight or appetite. Additionally, fluoxetine should be used cautiously in combination with other medications, as it may interact with certain drugs and lead to adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 439811-20-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,9,8,1 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 439811-20:
(8*4)+(7*3)+(6*9)+(5*8)+(4*1)+(3*1)+(2*2)+(1*0)=158
158 % 10 = 8
So 439811-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H12F3N/c1-2-9(14)7-3-5-8(6-4-7)10(11,12)13/h3-6,9H,2,14H2,1H3
439811-20-8Relevant articles and documents
Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases
Martínez-Montero, Lía,Gotor, Vicente,Gotor-Fernández, Vicente,Lavandera, Iván
, p. 474 - 480 (2017/06/23)
A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.
