439919-82-1

Basic information

• Product Name: methyl (2s,3aR,5r,6aS)-5-cyano-5-[4-methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl]octahydropentalene-2-carboxylate
• Synonyms: methyl (2s,3aR,5r,6aS)-5-cyano-5-[4-methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl]octahydropentalene-2-carboxylate
• CAS NO: 439919-82-1
• Molecular Weight: 399.487
• Mol File: 439919-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (2s,3aR,5r,6aS)-5-cyano-5-[4-methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl]octahydropentalene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2s,3aR,5r,6aS)-5-cyano-5-[4-methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl]octahydropentalene-2-carboxylate(439919-82-1)
• EPA Substance Registry System: methyl (2s,3aR,5r,6aS)-5-cyano-5-[4-methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl]octahydropentalene-2-carboxylate(439919-82-1)

Safety Data

• Hazardous Substances Data: 439919-82-1(Hazardous Substances Data)

Upstream product

• 2081-44-9 Tetrahydro-pyran-4-ol 
• 752259-59-9 methyl (2s,3aR,5r,6aS)-5-cyano-5-(3-hydroxy-4-methoxyphenyl)octahydropentalene-2-carboxylate 
• 752259-57-7 dimethyl 2,2'-[(1R,2S)-4-[3-(benzyloxy)-4-methoxyphenyl]-4-cyanocyclopentane-1,2-diyl]diacetate 
• 752259-58-8 (2s,3aR,6aS)-2-[3-(benzyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile 
• 752259-56-6 (3aR,7aS)-2-[3-(benzyloxy)-4-methoxyphenyl]-2,3,3a,4,7,7a-hexahydro-1H-indene-2-carbonitrile 

Downstream Products

• 439919-97-8 (2S,3aS,5R,6aR)-5-Cyano-5-[4-methoxy-3-(tetrahydro-pyran-4-yloxy)-phenyl]-octahydro-pentalene-2-carboxylic acid 

Relevant articles and documents

Orally active PDE4 inhibitor with therapeutic potential

Based on the promising results obtained by the clinical trial of Ariflo, further optimization of the spatial arrangement of the three pharmacophores (the carboxylic acid moiety, nitrile moiety and 3-cyclopentyloxy-4-methoxyphenyl moiety) in the