440-17-5 Usage
Description
Trifluoperazine dihydrochloride is a phenothiazine compound that functions as an antipsychotic agent. It exhibits anti-adrenergic and anti-dopaminergic actions, antagonizing adrenergic receptors with selectivity for α1 over the α2 subtypes. Trifluoperazine dihydrochloride also binds with high affinity to the dopamine D2-like receptor and has the ability to antagonize calmodulin (CaM), alter the calcium-binding properties of calsequestrin (CSQ), and activate type-2 ryanodine receptors.
Used in Pharmaceutical Industry:
Trifluoperazine dihydrochloride is used as an antipsychotic medication for its ability to manage symptoms associated with psychotic disorders by modulating neurotransmitter activity.
Used in Neurobiological Research:
Trifluoperazine dihydrochloride is used as a calmodulin kinase antagonist in cultured Aplysia californica neurons, aiding in the study of neuronal function and the role of calmodulin in synaptic plasticity.
Used in Physiological Research:
In mouse duodenal tissues, Trifluoperazine dihydrochloride is used as a PMCA (plasma membrane calcium ATPase) inhibitor to block the transcellular active calcium flux, which is crucial for understanding calcium transport mechanisms in the gastrointestinal system.
Therapeutic Function
Tranquilizer
Biochem/physiol Actions
Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.
Safety Profile
Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion. Experimental reproductive
effects. Human mutation data reported.
When heated to decomposition it emits very
toxic fumes of F-, NOx, SOx, and HCl. See
also FLUORIDES.
Purification Methods
Recrystallise the salt from absolute EtOH, filter the crystals, dry them in vacuo and store them in tightly stoppered bottles because it is hygroscopic. It is soluble in H2O but insoluble in *C6H6, Et2O and alkaline aqueous solution. It has UV at 258 and 307.5nm (log 4.50 and 3.50) in EtOH (neutral species). [Craig max et al. J Org Chem 22 709 1957.] It is a calmodulin inhibitor [Levene & Weiss J Parmacol Exptl Ther 208 454 1978] and is a psychotropic agent [Fowler Arzneim.-Forsch 27 866 1977]. [Beilstein 27 III/IV 1353.]
Check Digit Verification of cas no
The CAS Registry Mumber 440-17-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 0 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 440-17:
(5*4)+(4*4)+(3*0)+(2*1)+(1*7)=45
45 % 10 = 5
So 440-17-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H24F3N3S.ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;/h2-3,5-8,15H,4,9-14H2,1H3;1H
