440087-51-4

Basic information

• Product Name: 1-[4-(4-METHOXYPHENYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANAMINE
• Synonyms: 1-[4-(4-METHOXYPHENYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANAMINE;[4-(4-METHOXYPHENYL)OXAN-4-YL]METHANAMINE;{[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}amine;(4-(4-Methoxyphenyl)Tetrahydro-2H-Pyran-4-Yl)Methanamine(WXC01822)
• CAS NO: 440087-51-4
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.298
• Mol File: 440087-51-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-[4-(4-METHOXYPHENYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4-METHOXYPHENYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANAMINE(440087-51-4)
• EPA Substance Registry System: 1-[4-(4-METHOXYPHENYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANAMINE(440087-51-4)

Safety Data

• Hazardous Substances Data: 440087-51-4(Hazardous Substances Data)

Usage

General Description

1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methanamine is a chemical compound with the molecular formula C15H21NO2. It is a derivative of tetrahydro-2H-pyran and has a methoxyphenyl group attached to the tetrahydro-2H-pyran ring. The compound also contains a methanamine group, which is connected to the tetrahydro-2H-pyran ring. This chemical may have potential applications in the pharmaceutical industry or in academic research, particularly in the study of the structure-activity relationships of related compounds. Further research is needed to fully understand the properties and potential uses of this chemical.

Upstream product

• 3648-78-0 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 694485-33-1 N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethyl]carbamoylphenyl}benzamide 
• 664993-53-7 N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide 
• 664993-48-0 N-{[1-(3,4-dimethoxyphenyl)cyclopentyl]meth-yl}-N′-{[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}oxamide 

Relevant articles and documents

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

Tetrahydropyran derivative 1 was discovered in a high-throughput screening campaign to find new inhibitors of mycobacterial InhA. Following initial in-vitro profiling, a structure-activity relationship study was initiated and a focused library of analogs was synthesized and evaluated. This yielded compound 42 with improved antimycobacterial activity and low cytotoxicity. Additionally, the crystal structure of InhA in complex with inhibitor 1 was resolved, to reveal the binding mode and provide hints for further optimization.

3- Or 4-monosubstituted phenol derivatives useful as H3 ligands

The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.