441054-54-2 Usage
General Description
5-[4-(methylsulfonyl)phenyl]-2H-Tetrazole, also known as Temozolomide, is a cytotoxic and alkylating antineoplastic agent used in the treatment of various types of cancer, such as brain tumors and melanoma. It works by disrupting the growth and spread of cancer cells in the body. Temozolomide is a prodrug that is converted to the active metabolite, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC), which then alkylates DNA, leading to cell death. The drug is usually administered orally or intravenously, and its side effects may include nausea, vomiting, and myelosuppression. Temozolomide is a valuable tool in the treatment of cancer and offers hope for patients with these debilitating diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 441054-54-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,1,0,5 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 441054-54:
(8*4)+(7*4)+(6*1)+(5*0)+(4*5)+(3*4)+(2*5)+(1*4)=112
112 % 10 = 2
So 441054-54-2 is a valid CAS Registry Number.
441054-54-2Relevant articles and documents
5-Aryltetrazoles from Direct C-H Arylation with Aryl Bromides
Zhang, Yuan,Lee, Jack Chang Hung,Reese, Matthew R.,Boscoe, Brian P.,Humphrey, John M.,Helal, Christopher J.
, p. 5718 - 5723 (2020/05/19)
A mild, direct C-H arylation of 1-substituted tetrazoles to 5-aryltetrazoles is developed using a Pd/Cu cocatalytic system with readily available aryl bromides. The methodology avoids late-stage usage of azides and tolerates a wide range of functionalities.
