441351-31-1

Basic information

• Product Name: trans-3,5-dimethoxy-4'-tert-butyldimethylsilyloxystilbene
• Synonyms: trans-3,5-dimethoxy-4'-tert-butyldimethylsilyloxystilbene
• CAS NO: 441351-31-1
• Molecular Weight: 370.564
• Mol File: 441351-31-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: trans-3,5-dimethoxy-4'-tert-butyldimethylsilyloxystilbene(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3,5-dimethoxy-4'-tert-butyldimethylsilyloxystilbene(441351-31-1)
• EPA Substance Registry System: trans-3,5-dimethoxy-4'-tert-butyldimethylsilyloxystilbene(441351-31-1)

Safety Data

• Hazardous Substances Data: 441351-31-1(Hazardous Substances Data)

Upstream product

• 24131-30-4 (3,5-dimethoxybenzyl)triphenylphosphonium bromide 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 877-88-3 3,5-dimethoxybenzyl bromide 

Downstream Products

• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 537-42-8 3,5-dimethoxy-4'-hydroxy-trans-stilbene 

Relevant articles and documents

Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers

New carbon-11 and fluorine-18 labeled stilbene derivatives, cis-3,5-dimethoxy-4′-[11C]methoxystilbene (4′-[11C]8a), cis-3,4′,5-trimethoxy-3′-[11C]methoxystilbene (3′-[11C]8b), trans-3,5-dimethoxy-4′-[11C]methoxystilbene (4′-[11C]10a), trans-3,4′,5-trimethoxy-3′-[11C]methoxystilbene (3′-[11C]10b), cis-3,5-dimethoxy-4′-[18F]fluorostilbene (4′-[18F]12a), and trans-3,5-dimethoxy-4′-[18F]fluorostilbene (4′-[18F]13a), were designed and synthesized as potential PET probes for aryl hydrocarbon receptor (AhR) in cancers.

Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate

As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4 phosphate (2b), syntheses of certain related stilbenes (14) and benzophenones (16) were undertaken. The trimethyl ether derivative of (Z)-resveratrol (4a) exhibited the strongest activity (GI50 = 0.01-0.001 μg/mL) against a minipanel of human cancer cell lines. A monodemethylated derivative (14c) was converted to prodrug 14n (sodium resverastatin phosphate) for further biological evaluation. The antitubulin and antimicrobial activities of selected compounds were also evaluated.