4414-83-9

Basic information

• Product Name: 2-Chloro-10H-phenothiazine-10-propanenitrile
• Synonyms: 2-Chloro-10H-phenothiazine-10-propanenitrile;3-(2-chloro-10H-phenothiazin-10-yl)propanenitrile
• CAS NO: 4414-83-9
• Molecular Formula: C₁₅H₁₁ClN₂S
• Molecular Weight: 286.78
• Mol File: 4414-83-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 490°C at 760 mmHg
• Flash Point: 250.2°C
• Appearance: /
• Density: 1.327g/cm³
• Vapor Pressure: 9.47E-10mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 2-Chloro-10H-phenothiazine-10-propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-10H-phenothiazine-10-propanenitrile(4414-83-9)
• EPA Substance Registry System: 2-Chloro-10H-phenothiazine-10-propanenitrile(4414-83-9)

Safety Data

• Hazardous Substances Data: 4414-83-9(Hazardous Substances Data)

Usage

Description

2-Chloro-10H-phenothiazine-10-propanenitrile is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its phenothiazine core structure, with a chlorine atom at the 2nd position and a cyano group attached to the 10th position. 2-Chloro-10H-phenothiazine-10-propanenitrile plays a significant role in the development of medications with antiemetic and antipsychotic properties.

Uses

Used in Pharmaceutical Industry:
2-Chloro-10H-phenothiazine-10-propanenitrile is used as a key intermediate in the synthesis of Didesmethylchlorpromazine Hydrochloride (D440905), which is an impurity of Chlorpromazine (C424750). Chlorpromazine is a medication with antiemetic (anti-nausea) and antipsychotic properties, making it valuable in the treatment of various psychiatric disorders and nausea associated with conditions like cancer and chemotherapy.
2-Chloro-10H-phenothiazine-10-propanenitrile's role in the pharmaceutical industry is essential, as it contributes to the development of drugs that can alleviate symptoms and improve the quality of life for patients suffering from mental health issues and those undergoing harsh medical treatments.

InChI:InChI=1/C15H11ClN2S/c16-11-6-7-15-13(10-11)18(9-3-8-17)12-4-1-2-5-14(12)19-15/h1-2,4-7,10H,3,9H2

Upstream product

• 101-17-7 3-chlorodiphenylamine 
• 92-39-7 2-chlorophenothiazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 1225-64-5 Norchlorpromazine 
• 144456-56-4 3-(2-Chloro-phenothiazin-10-yl)-N-methyl-N-phenyl-propionamide 
• 2095-17-2 2-chloro-10-(3-aminopropyl)phenothiazine 
• 50-53-3 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine 
• 84-01-5 chlorproethazine 

Relevant articles and documents

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds

A new family of CaaX competitive inhibitors of human farnesyltransferase based on phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine moiety was designed, synthesized and biologically evaluated. Phenothiazine derivatives proved to be more active than carbazole-based compounds. Phenothiazine 1b with cysteine residue was the most promising inhibitor of human farnesyltransferase in the current study.

Synthesis of nor1- and nor2-chlorpromazine derivatives.

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